{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:35:59Z","timestamp":1790501759590,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,8,22]],"date-time":"2007-08-22T00:00:00Z","timestamp":1187740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2008,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We recently reported that, among bulimic women, previously abused carriers of the 5HTTLPR S allele showed special propensities towards novelty seeking (implying recklessness or impulsivity) and interpersonal insecurity. We subsequently re\u2010analyzed our data, to examine the bearing of the 5HTTLPR polymorphism and prior sexual or physical maltreatment upon validated, higher\u2010order personality\u2010traits. Ninety women with bulimic syndromes were genotyped for 5HTTLPR \u201cshort\u201d (S) and \u201clong\u201d (L<jats:sub>G<\/jats:sub> and L<jats:sub>A<\/jats:sub>) alleles, and then assessed for eating symptoms, history of sexual or physical abuse, and the higher\u2010order personality traits Emotional Dysregulation, Dissocial Behavior, Inhibition, and Compulsivity. With a classification based on a biallelic model of 5HTTLPR (i.e., presence or absence of at least one S\u2010allele copy), multiple regression indicated a significant proportion of variance in Dissocial Behavior to be explained by an abuse\u2009\u00d7\u2009genotype interaction\u2014greater psychopathology occurring in abused S\u2010allele carriers. A parallel analysis applying a triallelic model of 5HTTLPR (i.e., presence or absence of at least one copy of presumably low\u2010function S or L<jats:sub>G<\/jats:sub> alleles) produced a similar pattern, but no statistically significant effect. The finding that bulimic 5HTTLPR S\u2010allele carriers who are previously abused display elevations on Dissocial Behavior corroborates previous observations concerning phenomenological correlates of traumatic stress in 5HTTLPR S allele carriers. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30579","type":"journal-article","created":{"date-parts":[[2007,8,25]],"date-time":"2007-08-25T03:18:45Z","timestamp":1188011925000},"page":"128-130","source":"Crossref","is-referenced-by-count":30,"title":["Dissocial behavior, the 5HTTLPR polymorphism, and maltreatment in women with bulimic syndromes"],"prefix":"10.1002","volume":"147B","author":[{"given":"Howard","family":"Steiger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodie","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ridha","family":"Joober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimi","family":"Israel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth R.","family":"Bruce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.M.K.","family":"Ng Ying Kin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Howard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelie","family":"Anestin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Dandurand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Gauvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,8,22]]},"reference":[{"key":"e_1_2_3_2_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association (US)","year":"1994"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001336"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1521\/pedi.17.1.19.24055"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072290"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083968"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810070013002"},{"key":"e_1_2_3_8_1","first-page":"317","volume-title":"Binge eating: Nature, assessment and treatment","author":"Fairburn C","year":"1993"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.9.1329"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/503850"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902740211"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000080953"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.101.3.432"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.55.10.941"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000195746.52074.63"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(97)00356-9"},{"key":"e_1_2_3_17_1","first-page":"20","article-title":"Eating disorders and the serotonin connection: State, trait and developmental effects","volume":"29","author":"Steiger H","year":"2004","journal-title":"J Psychiatry Neurosci"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20073"},{"key":"e_1_2_3_19_1","article-title":"The 5HTTLPR polymorphism, prior maltreatment, and dramatic\u2010erratic personality manifestations in women with bulimic syndromes","author":"Steiger H","journal-title":"J Psychiatry Neuroscience"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.4.547"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291704004234"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.9.1588"}],"container-title":["American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.b.30579","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.30579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T23:26:04Z","timestamp":1697585164000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.b.30579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,22]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1,5]]}},"alternative-id":["10.1002\/ajmg.b.30579"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.b.30579","archive":["Portico"],"relation":{},"ISSN":["1552-4841","1552-485X"],"issn-type":[{"value":"1552-4841","type":"print"},{"value":"1552-485X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,22]]}}}