{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:53:15Z","timestamp":1763016795334},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2008,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gilles de la Tourette Syndrome (GTS) is an inherited neuropsychiatric disorder characterized by the presence of motor and phonic tics. Previous genetic studies have identified linkage and association between GTS and the 11q24 chromosomal region. We selected for study, within this region, two possible susceptibility genes for GTS, the <jats:italic>ROBO3<\/jats:italic> and <jats:italic>ROBO4<\/jats:italic> genes. These two genes were selected because of the recent identification of <jats:italic>SLITRK1<\/jats:italic> as a potential susceptibility gene for GTS based on a translocation breakpoint and the further finding of two mutations in the <jats:italic>SLITRK1<\/jats:italic> gene in three patients with GTS. While thus far, the <jats:italic>SLITRK1<\/jats:italic> gene appears to account for only a few cases of GTS, these findings, if confirmed, point to other genes in these pathways that may contribute to GTS. Based on this, we examined two genes in the Slit\u2010Robo pathway involved in cell migration, axonal pathfinding, and\/or neuronal differentiation because of their location in 11q24, a region previously identified as linked and associated with GTS. We selected six haplotype tagging single nucleotide polymorphisms (SNPs) for <jats:italic>ROBO3<\/jats:italic> and four for <jats:italic>ROBO4<\/jats:italic> and genotyped them in our sample of trios and sibpair families diagnosed with GTS. Based on 155 nuclear families with 255 affected children, we did not find evidence for association between GTS and either the <jats:italic>ROBO3<\/jats:italic> or <jats:italic>ROBO4<\/jats:italic> genes. Thus, these two genes are unlikely to be the susceptibility genes contributing to GTS on 11q24. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30580","type":"journal-article","created":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T20:50:57Z","timestamp":1186001457000},"page":"68-72","source":"Crossref","is-referenced-by-count":10,"title":["Association study between gilles de la tourette syndrome and two genes in the robo\u2010slit pathway located in the chromosome 11q24 linked\/associated 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