{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:09:27Z","timestamp":1791266967568,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,1,11]],"date-time":"2008-01-11T00:00:00Z","timestamp":1200009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2008,6,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several lines of evidence indicate a role of mutations in the two X\u2010linked genes neuroligin 3 (<jats:italic>NLGN3<\/jats:italic>) and neuroligin 4 (<jats:italic>NLGN4X<\/jats:italic>) in the etiology of autistic spectrum disorders. To analyze whether genetic variants in the <jats:italic>NLGN3<\/jats:italic> and <jats:italic>NLGN4X<\/jats:italic> genes occurs in patients with autistic disorders on high functioning level, we performed a mutation screen of both genes using SSCP in 107 probands with Asperger syndrome, high\u2010functioning autism and atypical autism. We identified four polymorphisms (rs2290488, rs7049300, rs3747333, rs3747334) and one novel synonymous variant (A558) in the <jats:italic>NLGN4X<\/jats:italic>. The polymorphisms rs7049300, rs3747333, and rs3747334 did not cause any amino acid substitutions in the total of the eight detected carriers. A family\u2010based association study for rs2290488 in 101 trios did not reveal association of this polymorphism with autistic disorders on high functioning level. We conclude that there is no evidence for an involvement of <jats:italic>NLGN3<\/jats:italic> and <jats:italic>NLGN4X<\/jats:italic> genetic variants with autism spectrum disorder on high functioning level in our study group. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30618","type":"journal-article","created":{"date-parts":[[2008,1,11]],"date-time":"2008-01-11T18:47:50Z","timestamp":1200077270000},"page":"535-537","source":"Crossref","is-referenced-by-count":45,"title":["No evidence for involvement of genetic variants in the X\u2010linked neuroligin genes <i>NLGN3<\/i> and <i>NLGN4X<\/i> in probands with autism spectrum disorder on high functioning level"],"prefix":"10.1002","volume":"147B","author":[{"given":"Anne\u2010Kathrin","family":"Wermter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Kamp\u2010Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Strauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Schulte\u2010K\u00f6rne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Remschmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,5,20]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30078"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1115455"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30287"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh158"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.11.003"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.10252"},{"issue":"10","key":"e_1_2_3_8_1","first-page":"3","article-title":"Epidemiology 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