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In 2002 we observed genome\u2010wide significant evidence of linkage to a region on chromosome 10q11.23\u2013q21.3 [Myers et al. (2002) Am J Med Genet 114:235\u2013244]. Our objective in this study was to test every gene within the maximum LOD\u20101 linkage region, for association with LOAD. We obtained results for 528 SNPs from 67 genes, with an average density of 1 SNP every 10 kb within the genes. We demonstrated nominally significant association with LOAD for 4 SNPs: rs1881747 near <jats:italic>DKK1<\/jats:italic> (<jats:italic>P<\/jats:italic>\u2009=\u20090.011, OR\u2009=\u20091.24), rs2279420 in <jats:italic>ANK3<\/jats:italic> (<jats:italic>P<\/jats:italic>\u2009=\u20090.022, OR\u2009=\u20090.79), rs2306402 in <jats:italic>CTNNA3<\/jats:italic> (<jats:italic>P<\/jats:italic>\u2009=\u20090.024, OR\u2009=\u20091.18), and rs5030882 in <jats:italic>CXXC6<\/jats:italic> (<jats:italic>P<\/jats:italic>\u2009=\u20090.046, OR\u2009=\u20091.29) in 1,160 cases and 1,389 controls. These results would not survive correction for multiple testing but warrant attempts at confirmation in independent samples. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30670","type":"journal-article","created":{"date-parts":[[2007,12,28]],"date-time":"2007-12-28T18:19:26Z","timestamp":1198865966000},"page":"727-731","source":"Crossref","is-referenced-by-count":32,"title":["Association analysis of 528 intra\u2010genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's 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