{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:39:59Z","timestamp":1779363599248,"version":"3.53.0"},"reference-count":64,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,1,11]],"date-time":"2008-01-11T00:00:00Z","timestamp":1200009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2008,9,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Type 2 diabetes is a risk factor for late\u2010onset Alzheimer's disease (AD), and studies suggest that pathogenic effects of diabetes and insulin resistance may be associated with non\u2010APOE4 AD. Therefore, we examined association of the APOE4 allele with diabetes in an AD population. Retrospective and cross\u2010sectional clinical and APOE\u2010genotype data on 465 cases with probable or definite AD previously ascertained by the National Institute of Mental Health Genetics Initiative were analyzed by regression analysis. Dependent variables included presence of APOE4 alleles and AD onset age. Diabetes was the independent variable and covariates included gender, hypertension, and other potentially confounding variables. We also examined for interactions involving weight status as overweight and obesity are independent risk factors for insulin resistance, diabetes and AD. Prevalence of diabetes was 13% among AD cases without an APOE4 allele and 5\u20136% among AD cases with one or two APOE4 alleles. Odds ratio for diabetes was 0.26 [95% CI: 0.09\u20130.73; <jats:italic>P<\/jats:italic>\u2009=\u20090.011] by APOE4 status after adjusting for all covariates. Diabetes did not associate with AD onset age. Among other independent variables included in the model, APOE4 and diuretic medication treatment were associated with AD onset age. In a subset of cases with body mass index determinations, overweight also exhibited an inverse association with APOE4 and associated with decreased non\u2010APOE4 AD onset age. Pathogenic mechanisms associated with diabetes and overweight are enriched in AD cases without an APOE4 allele. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30694","type":"journal-article","created":{"date-parts":[[2008,1,11]],"date-time":"2008-01-11T16:46:31Z","timestamp":1200069991000},"page":"822-829","source":"Crossref","is-referenced-by-count":32,"title":["Diabetes and overweight associate with non\u2010APOE4 genotype in an alzheimer's disease population"],"prefix":"10.1002","volume":"147B","author":[{"given":"Louis A.","family":"Profenno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen V.","family":"Faraone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,8,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.11.1551"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.5.661"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1996.tb01362.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1994.00540240042014"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.1.139"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000176061.33817.90"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0062"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(04)00681-7"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(02)00087-2"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:17:1:45"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6823-5-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66378-7"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2572com"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.10.noc50112"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/27376"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(03)00163-2"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00426-7"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.8.991"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70526-9"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.13.1524"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1975.00490510088009"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20051029"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53301.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wad.0000213814.43047.86"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.31.19547"},{"key":"e_1_2_6_28_1","first-page":"221","article-title":"The behavior of maximum likelihood estimates under non\u2010standard conditions","volume":"1","author":"Huber PJ","year":"1967","journal-title":"Proc Fifth Berkeley Symp Math Stat Probab"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1166(200101)16:1<77::AID-GPS279>3.0.CO;2-G"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1985.04060100083029"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.5.noc60013"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.10.1556"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000216274.58185.09"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)00387-4"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7115.1045"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009106"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2004.09.017"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1027364121738"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/154.7.635"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000140292.04932.87"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000172914.08967.dc"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(96)00014-8"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000038910.46217.AA"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.9.1937"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.11.019"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.4.1256"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2004.09.023"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.03.016"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500369"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.3.321"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(00)00040-3"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2006.03.013"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi051"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.55.01.06.db05-1077"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.1.55"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf636"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2003.09.008"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.5.655"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000234037.91185.99"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-64-1-190"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.241406698"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1996.tb00912.x"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38446.466238.E0"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000140291.86406.D1"}],"container-title":["American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.b.30694","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.30694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T01:10:54Z","timestamp":1697591454000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.b.30694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,22]]},"references-count":64,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,9,5]]}},"alternative-id":["10.1002\/ajmg.b.30694"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.b.30694","archive":["Portico"],"relation":{},"ISSN":["1552-4841","1552-485X"],"issn-type":[{"value":"1552-4841","type":"print"},{"value":"1552-485X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,22]]}}}