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We conducted a family\u2010based association study of <jats:italic>SLC6A3<\/jats:italic> in 170 affected offspring trios defined by a child (12.9\u2009\u00b1\u20095.3 years of age)with DSM\u2010IV Bipolar\u2010I disorder. Twenty\u2010eight tag SNPs were chosen from the CEU (European) population of the International HapMap project (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.hapmap.org\/\">www.hapmap.org<\/jats:ext-link>). Results indicated nominally positive association for 4 SNPs (rs40184, rs11133767, rs3776512, and rs464049), but only rs40184 survived correction for multiple statistical comparisons (<jats:italic>P<\/jats:italic>\u2009=\u20090.038). This is the first examination of the association with <jats:italic>SLC6A3<\/jats:italic> and bipolar disorder in children and, like previous findings in adults with bipolar disorder, we found evidence of association with SNPs in the 3\u2032 region of the gene. These data provide suggestive evidence supporting a role for <jats:italic>SLC6A3<\/jats:italic> in the etiology of pediatric bipolar disorder. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30745","type":"journal-article","created":{"date-parts":[[2008,3,24]],"date-time":"2008-03-24T17:46:45Z","timestamp":1206380805000},"page":"1182-1185","source":"Crossref","is-referenced-by-count":36,"title":["Family based association study of pediatric bipolar disorder and the dopamine transporter gene (<i>SLC6A3<\/i>)"],"prefix":"10.1002","volume":"147B","author":[{"given":"Eric","family":"Mick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jang 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