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The genes encoding corticotropin releasing hormone receptor 1 (CRHR1), tachykinin receptor 1 (TACR1), gastrin releasing peptide (GRP), and gastrin releasing peptide receptor (GRPR) were selected as candidates for PD based on their biology. Linkage and association analysis in 120 multiplex U.S. PD pedigrees was performed using 21 single nucleotide polymorphisms (SNPs). Parametric and non\u2010parametric linkage tests in pedigrees, for single point and multipoint analysis, revealed limited support for genetic linkage to TACR1 (parametric and non\u2010parametric lod scores \u223c1). The family\u2010based association test (FBAT) generated nominal support for allelic association in TACR1 (<jats:italic>P<\/jats:italic>\u2009=\u20090.02), and GRP (<jats:italic>P<\/jats:italic>\u2009=\u20090.02), findings which must be considered in the light of multiple comparisons. 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