{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:51:21Z","timestamp":1776156681966,"version":"3.50.1"},"reference-count":78,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,5,2]],"date-time":"2008-05-02T00:00:00Z","timestamp":1209686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2009,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gilles de la Tourette Syndrome (TS) is a neuropsychiatric disorder characterized by both motor and vocal tics. In our previous genome scan for TS we identified evidence for linkage to the centromeric region of chromosome 5 in a single large family of 32 individuals with 10 family members with TS or chronic multiple tics (CMT). In this paper we report further analyses of the 5p\u2010centromeric region in this pedigree. An additional 11 family members were identified and screened for TS. Using a set of 14 microsatellite markers we refined the linked region to a \u223c28 Mb interval between the markers D5S1506 and D5S76. A set of six candidate genes located in this region were selected to be tested for genetic association with TS. These genes were <jats:italic>GDNF<\/jats:italic>, <jats:italic>ITGA1<\/jats:italic>, <jats:italic>ISL1<\/jats:italic>, <jats:italic>FGF10<\/jats:italic>, <jats:italic>HCN1<\/jats:italic> and <jats:italic>SLC1A3<\/jats:italic>. The TDT statistic was used for the association tests in a sample of 171 independent nuclear families with 241 affected children with TS. We found no evidence for an association between TS and markers in these genes in this sample of families. This study represents the first efforts to narrow the linkage region in the extended pedigree and the first tests of candidate genes in the chromosome 5 region linked to TS. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30779","type":"journal-article","created":{"date-parts":[[2008,5,4]],"date-time":"2008-05-04T02:52:40Z","timestamp":1209869560000},"page":"95-103","source":"Crossref","is-referenced-by-count":23,"title":["Chromosome 5 and Gilles de la Tourette syndrome: Linkage in a large pedigree and association study of six candidates in the region"],"prefix":"10.1002","volume":"150B","author":[{"given":"Nancy","family":"Laurin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen G.","family":"Wigg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Sandor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathy L.","family":"Barr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,5,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1116502"},{"key":"e_1_2_6_3_1","volume-title":"American Psychiatric Association: Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1987"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/375143"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.69062571.x"},{"key":"e_1_2_6_6_1","first-page":"379","volume-title":"Handbook of Tourette's syndrome and related tic and behavioral disorders","author":"Barr CL","year":"2005"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674379804300402"},{"key":"e_1_2_6_8_1","first-page":"S106","article-title":"Genome scan for linkage to Gilles de la Tourette syndrome","volume":"5","author":"Barr CL","year":"1995","journal-title":"Psychiatr Genet"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960531)67:3<301::AID-AJMG6>3.0.CO;2-P"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990820)88:4<437::AID-AJMG24>3.0.CO;2-E"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92555-V"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91064-S"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(94)00161-U"},{"key":"e_1_2_6_15_1","first-page":"31","article-title":"Complex segregation analysis of obsessive compulsive and spectrum related disorders","volume":"5","author":"Cavallini MC","year":"1995","journal-title":"Psychiatr Genet"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/302577"},{"issue":"3","key":"e_1_2_6_17_1","first-page":"586","article-title":"Detection of major gene for Gilles de la Tourette syndrome","volume":"36","author":"Comings DE","year":"1984","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03470130073032"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)93123-I"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.160.6.845"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2006.00706.x"},{"key":"e_1_2_6_22_1","volume-title":"SCL\u201090: Administration, scoring and procedures Manual\u2010I. 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