{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T21:08:51Z","timestamp":1766869731287},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,9,8]],"date-time":"2008-09-08T00:00:00Z","timestamp":1220832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2009,6,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alzheimer's disease (AD) is a complex and multifactorial disease with the possible involvement of several genes. With the exception of the <jats:italic>APOE<\/jats:italic> gene as a susceptibility marker, no other genes have been shown consistently to be associated with late\u2010onset AD (LOAD). A recent genome\u2010wide association study of 17,343 gene\u2010based putative functional single nucleotide polymorphisms (SNPs) found 19 significant variants, including 3 linked to <jats:italic>APOE<\/jats:italic>, showing association with LOAD (Hum Mol Genet 2007; 16:865\u2013873). We have set out to replicate the 16 new significant associations in a large case\u2010control cohort of American Whites. Additionally, we examined six variants present in positional and\/or biological candidate genes for AD. We genotyped the 22 SNPs in up to 1,009 Caucasian Americans with LOAD and up to 1,010 age\u2010matched healthy Caucasian Americans, using 5\u2032 nuclease assays. We did not observe a statistically significant association between the SNPs and the risk of AD, either individually or stratified by <jats:italic>APOE<\/jats:italic>. Our data suggest that the association of the studied variants with LOAD risk, if it exists, is not statistically significant in our sample. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30851","type":"journal-article","created":{"date-parts":[[2008,9,8]],"date-time":"2008-09-08T13:39:17Z","timestamp":1220881157000},"page":"520-526","source":"Crossref","is-referenced-by-count":11,"title":["Association studies of 22 candidate SNPs with late\u2010onset Alzheimer's disease"],"prefix":"10.1002","volume":"150B","author":[{"given":"Jessica A.","family":"Figgins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan L.","family":"Minster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. Yesim","family":"Demirci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven T.","family":"DeKosky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Ilyas","family":"Kamboh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,9,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000845"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/521952"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/302710"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe078130"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-2456(98)00037-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.2.168"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm031"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8817.2004.00110.x"},{"key":"e_1_2_6_10_1","first-page":"848","article-title":"The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain: An immunocytochemical study","volume":"146","author":"Lemere CA","year":"1995","journal-title":"Am J Pathol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/339815"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3110299"},{"key":"e_1_2_6_13_1","unstructured":"R Development Core Team.2005.R: A language and environment for statistical computing version 2.2.0. 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Foundation for Statistical Computing Vienna Austria.www.r\u2010project.org."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072366"}],"container-title":["American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.b.30851","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.30851","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:17:37Z","timestamp":1697674657000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.b.30851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,8]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,6,5]]}},"alternative-id":["10.1002\/ajmg.b.30851"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.b.30851","archive":["Portico"],"relation":{},"ISSN":["1552-4841","1552-485X"],"issn-type":[{"value":"1552-4841","type":"print"},{"value":"1552-485X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,8]]}}}