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We analyzed five main psychiatric diagnostic categories (substance\u2010abuse, anxiety, eating, psychotic, and mood disorders) and two different control groups, representing a total of 3,214 samples, for 748 promoter and non\u2010synonymous single nucleotide polymorphisms (SNPs) at 306 genes involved in neurotransmission and\/or neurodevelopment. We identified strong associations to individual disorders, such as growth hormone releasing hormone (GHRH) with anxiety disorders, prolactin regulatory element (PREB) with eating disorders, ionotropic kainate glutamate receptor 5 (GRIK5) with bipolar disorder and several SNPs associated to several disorders, that may represent individual and related disease susceptibility factors. Remarkably, a functional SNP, rs945032, located in the promoter region of the bradykinin receptor B2 gene (BDKRB2) was associated to three disorders (panic disorder, substance abuse, and bipolar disorder), and two additional BDKRB2 SNPs to obsessive\u2010compulsive disorder and major depression, providing evidence for common variants of susceptibility to several related psychiatric disorders. The association of BDKRB2 (odd ratios between 1.65 and 3.06) to several psychiatric disorders supports the view that a common genetic variant could confer susceptibility to clinically related phenotypes, and defines a new functional hint in the pathophysiology of psychiatric diseases. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30902","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T13:08:48Z","timestamp":1229000928000},"page":"808-816","source":"Crossref","is-referenced-by-count":86,"title":["Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non\u2010synonymous SNPs of 306 genes involved in neurotransmission and 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