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Only one previous linkage study has published findings on NW [Swan et al. (2006); Am J Med Genet Part B 141B:354\u2013360; LOD\u2009=\u20092.7; Chr. 6 at 159 cM]. As part of an international consortium, genome\u2010wide scans (using over 360 autosomal microsatellite markers) and telephone diagnostic interviews were conducted on 289 Australian (AUS) and 161 Finnish (FIN, combined (COMB) N\u2009=\u2009450 families) families ascertained from twin registries through index\u2010cases with a lifetime history of cigarette smoking. The statistical approach used an affected\u2010sib\u2010pair design (at least two adult full siblings reported a history of DSM\u2010IV NW) and conducted the linkage analyses using MERLIN. Linkage signals with LOD scores &gt;1.5 were found on two chromosomes: 6 (FIN: LOD\u2009=\u20091.93 at 75 cM) and 11 at two different locations (FIN: LOD\u2009=\u20093.55 at 17 cM, and AUS: LOD\u2009=\u20091.68 with a COMB: LOD\u2009=\u20092.30 at 123 cM). The multipoint LOD score of 3.55 on chromosome 11p15 in FIN met genomewide significance (<jats:italic>P<\/jats:italic>\u2009=\u20090.013 with 1,000 simulations). At least four strong candidate genes lie within or near this peak on chromosome 11: <jats:italic>DRD4, TPH, TH<\/jats:italic>, and <jats:italic>CHRNA10<\/jats:italic>. Other studies have reported that chromosome 11 may harbor genes associated with various aspects of smoking behavior. This study adds to that literature by highlighting evidence for NW. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30924","type":"journal-article","created":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T23:13:35Z","timestamp":1233270815000},"page":"950-959","source":"Crossref","is-referenced-by-count":19,"title":["Genetic linkage findings for DSM\u2010IV nicotine withdrawal in two populations"],"prefix":"10.1002","volume":"150B","author":[{"given":"Michele L.","family":"Pergadia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arpana","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anu","family":"Loukola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant 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