{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:24:13Z","timestamp":1790144653977,"version":"4.0.1"},"reference-count":58,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T00:00:00Z","timestamp":1233619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2009,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Disrupted\u2010in\u2010Schizophrenia 1 (DISC1) and its molecular cascade have been implicated in the pathophysiology of major psychoses. Previously, we identified pericentrin 2 (PCNT2) and DISC1\u2010binding zinc finger protein (DBZ) as binding partners of DISC1; further, we observed elevated expression of\n                    <jats:italic>PCNT2<\/jats:italic>\n                    in the postmortem brains and in the lymphocytes of bipolar disorder patients, compared to controls. Here, we examined the association of\n                    <jats:italic>PCNT2<\/jats:italic>\n                    with schizophrenia in a case\u2013control study of Japanese cohorts. We also examined the association of\n                    <jats:italic>DBZ<\/jats:italic>\n                    with schizophrenia and with bipolar disorder, and compared the mRNA levels of\n                    <jats:italic>DBZ<\/jats:italic>\n                    in the postmortem brains of schizophrenia, bipolar and control samples. DNA from 180 schizophrenia patients 201 controls were used for the association study of\n                    <jats:italic>PCNT2<\/jats:italic>\n                    and\n                    <jats:italic>DBZ<\/jats:italic>\n                    with schizophrenia. Association of\n                    <jats:italic>DBZ<\/jats:italic>\n                    with bipolar disorder was examined in DNA from 238 bipolar patients and 240 age\u2010 and gender\u2010matched controls. We observed significant allelic and genotypic associations of the\n                    <jats:italic>PCNT2<\/jats:italic>\n                    SNPs, rs2249057, rs2268524, and rs2073380 (Ser\/Arg) with schizophrenia; the association of rs2249057 (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.002) withstand multiple testing correction. Several two SNP\u2010 and three SNP\u2010haplotypes showed significant associations; the associations of haplotypes involving rs2249057 withstand multiple testing correction. No associations were observed for\n                    <jats:italic>DBZ<\/jats:italic>\n                    with schizophrenia or with bipolar disorder; further, there was no significant difference between the\n                    <jats:italic>DBZ<\/jats:italic>\n                    mRNA levels of control, schizophrenia and bipolar postmortem brains. We suggest a possible role of PCNT2 in the pathogenesis of schizophrenia. Abnormalities of PCNT2, the centrosomal protein essential for microtubule organization, may be suggested to lead to neurodevelopmental abnormalities. \u00a9 2009 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ajmg.b.30926","type":"journal-article","created":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T10:14:07Z","timestamp":1233656047000},"page":"967-976","source":"Crossref","is-referenced-by-count":28,"title":["Association studies and gene expression analyses of the DISC1\u2010interacting molecules, pericentrin 2 (\n                    <i>PCNT2<\/i>\n                    ) and DISC1\u2010binding zinc finger protein (\n                    <i>DBZ<\/i>\n                    ), with schizophrenia and with bipolar 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