{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T19:40:29Z","timestamp":1760730029886},"reference-count":52,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,2,6]],"date-time":"2009-02-06T00:00:00Z","timestamp":1233878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2009,12,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The polymorphism in the serotonin transporter gene promoter region (5\u2010HTTLPR) is by far the most studied variant hypothesized to influence Neuroticism\u2010related personality traits. The results of previous studies have been mixed and appear moderated by the personality questionnaire used. Studies that used the TCI to assess Harm Avoidance or the EPQ to assess Neuroticism have found no association with the 5\u2010HTTLPR. However, studies that used the NEO\u2010PI\u2010R or related instruments (NEO\u2010PI, NEO\u2010FFI) to measure Neuroticism have found some evidence of association. This study examines the association of variants in the serotonin transporter gene in a sample from a genetically isolated population within Sardinia (Italy) that is several times larger than previous samples that used the NEO\u2010PI\u2010R (N\u2009=\u20093,913). The association was also tested in a sample (N\u2009=\u2009548) from the Baltimore Longitudinal Study of Aging (BLSA), in which repeated NEO\u2010PI\u2010R assessments were obtained. In the SardiNIA sample, we found no significant association of the 5\u2010HTTLPR genotypes with Neuroticism or its facets (Anxiety, Angry\u2010Hostility, Depression, Self\u2010Consciousness, Impulsiveness, and Vulnerability). In the BLSA sample, we found lower scores on Neuroticism traits for the heterozygous group, which is inconsistent with previous studies. We also examined eight SNPs in the SardiNIA (N\u2009=\u20093,972) and nine SNPs in the BLSA (N\u2009=\u20091,182) that map within or near the serotonin transporter gene (SLC6A4), and found no association. Along with other large studies that used different phenotypic measures and found no association, this study substantially increases the evidence against a link between 5\u2010HTT variants and Neuroticism\u2010related traits. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30932","type":"journal-article","created":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T07:37:17Z","timestamp":1233992237000},"page":"1070-1077","source":"Crossref","is-referenced-by-count":34,"title":["Variants of the serotonin transporter gene and NEO\u2010PI\u2010R Neuroticism: No association in the BLSA and SardiNIA 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