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We calculated 2\u2010point lodscores maximized over male and female recombination fractions by classifying individuals with PD and\/or BP as affected (PD\u2009+\u2009BP). Additionally, to shed light on possible heterogeneity, we examine the pedigrees containing a bipolar member (BP+) separately from those that do not (BP\u2212), using a Predivided\u2010Sample Test (PST). Linkage evidence for common genes for PD\u2009+\u2009BP was obtained on chromosomes 2 (lodscore\u2009=\u20094.6) and chromosome 12 (lodscore\u2009=\u20093.6). These locations had already been implicated using a PD\u2010only diagnosis, although at both locations this was larger when a joint PD\u2009+\u2009BP diagnosis was used. Examining the BP+ families and BP\u2212 families separately indicates that both BP+ and BP\u2212 pedigrees are contributing to the peaks on chromosomes 2 and 12. However, the PST indicates different evidence of linkage is obtained from BP+ and BP\u2212 pedigrees on chromosome 13. Our findings are consistent with risk loci for the combined PD\u2009+\u2009BP phenotype on chromosomes 2 and 12. We also obtained evidence of heterogeneity on chromosome 13. The regions on chromosomes 12 and 13 identified here have previously been implicated as regions of interest for multiple psychiatric disorders, including BP. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30939","type":"journal-article","created":{"date-parts":[[2009,3,23]],"date-time":"2009-03-23T13:59:33Z","timestamp":1237816773000},"page":"1139-1146","source":"Crossref","is-referenced-by-count":9,"title":["A linkage search for joint panic disorder\/bipolar genes"],"prefix":"10.1002","volume":"150B","author":[{"given":"Mark W.","family":"Logue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Durner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary A.","family":"Heiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan E.","family":"Hodge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven P.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Knowles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abby J.","family":"Fyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myrna M.","family":"Weissman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,3,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/379978"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000922"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00805795"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/1734"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.10030"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674379403900205"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/302579"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.2.280"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001453"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001778"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.182412499"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ypg.0000056684.89558.d2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2272(200012)19:4<366::AID-GEPI8>3.0.CO;2-F"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320600203"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.01.019"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.10.5604"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1043"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/00048679809073872"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg199"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.11.016"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041444-199800830-00002"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/497703"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10601"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","unstructured":"FyerAJ WeissmanMM.1999.Genetic linkage study of panic: Clinical methodology and description of pedigrees. 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