{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:33:38Z","timestamp":1790890418037,"version":"4.1.0"},"reference-count":77,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We examined associations between haplotypes of the serotonin 1B receptor gene and individual differences in anger and hostility. Data were analyzed from a study of 361 university students (47% male). Participants were genotyped at five polymorphisms in the<jats:italic>HTR1B<\/jats:italic>gene (rs11568817, rs130058, rs6296, rs6297, rs13212041), including promoter and 3\u2032UTR polymorphisms with opposite functional effects on gene expression. Participants reported their emotional states across 30 consecutive days for up to 4 years. Haplotype pairs were constructed statistically and assigned to a level of<jats:italic>HTR1B<\/jats:italic>expression based on the presence of the functional polymorphisms. Six haplotypes accounted for &gt;97% of chromosomes. Three low expression haplotypes contained the 3\u2032UTR variant (rs13212041 A\u2010allele) that enables a microRNA\u2010mediated reduction in expression. One intermediate expression haplotype contained the 3\u2032UTR A\u2010allele paired with the high\u2010activity promoter. Two high expression haplotypes contained the 3\u2032UTR variant (rs13212041 G\u2010allele) that attenuates microRNA\u2010mediated reduction in expression. Men with low expression haplotypes reported greater anger and hostility than men with one or two high expression haplotypes. Diplotype classification accounted for 8.4% of the variance in men's anger and hostility, primarily due to the 3\u2032UTR polymorphism (rs13212041), but with some contribution of the functional promoter combination (rs11568817, rs130058). Associations with anger and hostility were not found in women. These findings extend our understanding of the genetic basis of anger and hostility by showing that newly characterized<jats:italic>HTR1B<\/jats:italic>haplotypes, particularly those with rs13212041, which modulates microRNA\u2010mediated regulation of<jats:italic>HTR1B<\/jats:italic>expression, may have important implications for aggression\u2010related phenotypes among young men. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30955","type":"journal-article","created":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T13:46:05Z","timestamp":1239025565000},"page":"67-78","source":"Crossref","is-referenced-by-count":61,"title":["Functional polymorphisms in the serotonin 1B receptor gene (<i>HTR1B<\/i>) predict self\u2010reported anger and hostility among young men"],"prefix":"10.1002","volume":"153B","author":[{"given":"Tamlin S.","family":"Conner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin 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