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The impact of these variations on other psychiatric disorders has not been yet investigated. Caucasian non\u2010Hispanic participants in the STAR*D study of treatment for depression for whom DNA was available (N\u2009=\u20091213) were genotyped at two single\u2010nucleotide polymorphisms (SNPs) (rs10848635 and rs1006737) in the <jats:italic>CACNA1C<\/jats:italic> gene. We examined putative phenotypic indicators of bipolarity among patients with major depression and elements of longitudinal course suggestive of latent bipolarity. We also considered remission and depression severity following citalopram treatment. The rs10848635 risk allele was significantly associated with lower levels of baseline agitation (<jats:italic>P<\/jats:italic>\u2009=\u20090.03; \u03b2\u2009=\u2009\u22120.09). The rs1006737 risk allele was significantly associated with lesser baseline depression severity (<jats:italic>P<\/jats:italic>\u2009=\u20090.04; \u03b2\u2009=\u2009\u22120.4) and decreased likelihood of insomnia (<jats:italic>P<\/jats:italic>\u2009=\u20090.047; \u03b2\u2009=\u2009\u22120.22). Both markers were associated with an increased risk of citalopram\u2010emergent suicidality (rs10848635: OR\u2009=\u20091.29, <jats:italic>P<\/jats:italic>\u2009=\u20090.04; rs1006737: OR\u2009=\u20091.34, <jats:italic>P<\/jats:italic>\u2009=\u20090.02). In this exploratory analysis, treatment\u2010emergent suicidality was associated with two risk alleles in a putative bipolar liability gene. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30962","type":"journal-article","created":{"date-parts":[[2009,4,22]],"date-time":"2009-04-22T15:03:07Z","timestamp":1240412587000},"page":"303-309","source":"Crossref","is-referenced-by-count":37,"title":["Phenotypic effects of a bipolar liability gene among individuals with major depressive disorder"],"prefix":"10.1002","volume":"153B","author":[{"given":"Francesco","family":"Casamassima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Fava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary 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