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In this study, markers across the 6p region were tested for association with RD. Our strongest findings were for association with markers in <jats:italic>KIAA0319<\/jats:italic>, although with the opposite alleles compared with a previous study. We also found association with markers in <jats:italic>VMP<\/jats:italic>, but not with <jats:italic>DCDC2<\/jats:italic>. Current evidence indicates that differential regulation of <jats:italic>KIAA0319<\/jats:italic> and <jats:italic>DCDC2<\/jats:italic> contributes to RD, thus we used chromatin immunoprecipitation coupled with genomic tiling arrays (ChIP\u2010chip) to map acetylated histones, a molecular marker for regulatory elements, across a 500\u2009kb genomic region covering the RD locus on 6p. This approach identified several regions marked by acetylated histones that mapped near associated markers, including intron 7 of <jats:italic>DCDC2<\/jats:italic> and the 5\u2032 region of <jats:italic>KIAA0319<\/jats:italic>. The latter is located within the 70\u2009kb region previously associated with differential expression of <jats:italic>KIAA0319<\/jats:italic>. Interestingly, five markers associated with RD in independent studies were also located within the 2.7\u2009kb acetylated region, and six additional associated markers, including the most significant one in this study, were located within a 22\u2009kb haplotype block that encompassed this region. Our data indicates that this putative regulatory region is a likely site of genetic variation contributing to RD in our sample, further narrowing the candidate region. \u00a9 2009 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Published by Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30999","type":"journal-article","created":{"date-parts":[[2009,7,10]],"date-time":"2009-07-10T01:02:38Z","timestamp":1247187758000},"page":"447-462","source":"Crossref","is-referenced-by-count":45,"title":["Association of reading disabilities with regions marked by acetylated H3 histones in <i>KIAA0319<\/i>"],"prefix":"10.1002","volume":"153B","author":[{"given":"Jillian M.","family":"Couto","sequence":"first","affiliation":[{"name":"Genetics and Development Division, Toronto Western Research Institute, Toronto Western Hospital University Health Network  Toronto, Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izzy","family":"Livne\u2010Bar","sequence":"additional","affiliation":[{"name":"Genetics and Development Division, Toronto Western Research Institute, Toronto Western Hospital University Health Network  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