{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:21:49Z","timestamp":1790238109171,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,9,23]],"date-time":"2009-09-23T00:00:00Z","timestamp":1253664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An increasing number of animal studies advert to a substantial role of the neuropeptide oxytocin in the regulation of social attachment and affiliation. Furthermore, animal studies showed anxiety and stress\u2010reduced effects of oxytocin. First human studies confirm these findings in animal studies and implicate a crucial role of oxytocin in human social attachment behavior and in social interactions. Thus, the oxytocin system might be involved in the impairment of social interaction and attachment in autism spectrum disorders (ASD). The human <jats:italic>oxytocin receptor<\/jats:italic> gene (<jats:italic>OXTR<\/jats:italic>) represents a plausible candidate gene for the etiology of ASD. To analyze whether genetic variants in the <jats:italic>OXTR<\/jats:italic> gene are associated with ASD we performed family\u2010based single\u2010marker and haplotype association analyses with 22 single nucleotide polymorphisms (SNPs) in the <jats:italic>OXTR<\/jats:italic> and its 5\u2032 region in 100 families with autistic disorders on high\u2010functioning level (Asperger syndrome (AS), high\u2010functioning autism (HFA), and atypical autism (AA)). Single\u2010marker and haplotype association analyses revealed nominally significant associations of one single SNP and one haplotype with autism, respectively. Furthermore, employing a \u201creverse phenotyping\u201d approach, patients carrying the haplotype associated with autism showed nominally significant impairments in comparison to noncarriers of the haplotype in items of the Autism Diagnostic Interview\u2010Revised algorithm describing aspects of social interaction and communication. In conclusion, our results implicate that genetic variation in the <jats:italic>OXTR<\/jats:italic> gene might be relevant in the etiology of autism on high\u2010functioning level. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.31032","type":"journal-article","created":{"date-parts":[[2009,9,23]],"date-time":"2009-09-23T17:35:30Z","timestamp":1253727330000},"page":"629-639","source":"Crossref","is-referenced-by-count":140,"title":["Evidence for the involvement of genetic variation in the <i>oxytocin receptor<\/i> gene (<i>OXTR<\/i>) in the etiology of autistic disorders on high\u2010functioning level"],"prefix":"10.1002","volume":"153B","author":[{"given":"Anne\u2010Kathrin","family":"Wermter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Kamp\u2010Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Hesse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Schulte\u2010K\u00f6rne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Strauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Remschmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2006.06.018"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)00435-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.10323"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/424390"},{"key":"e_1_2_6_7_1","unstructured":"B\u00f6lteS R\u00fchlD Schm\u00f6tzerG PoustkaF.2006.ADI\u2010R Diagnostisches Interview f\u00fcr Autismus \u2010 Revidiert. 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