{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:56:18Z","timestamp":1763016978426,"version":"3.37.3"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,9,23]],"date-time":"2009-09-23T00:00:00Z","timestamp":1253664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute for Neurological Disorders and Stroke","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000092","name":"National Library of Medicine","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000092","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"crossref","award":["U01NS040024","T15 LM07124","K07 CA98364","UL1-RR025764","C06-RR11234"],"award-info":[{"award-number":["U01NS040024","T15 LM07124","K07 CA98364","UL1-RR025764","C06-RR11234"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tourette syndrome (TS) is a neuropsychiatric disorder characterized by multiple motor and phonic tics. The heritability of TS has been well established, yet there is a lack of consensus in genome\u2010wide linkage studies. The purpose of this study was to conduct a genome\u2010wide linkage analysis on a unique, large, high\u2010risk TS Utah pedigree. We examined a qualitative trait (TS1) where cases had a definitive diagnosis of TS as observed by a clinical interviewer (n\u2009=\u200966) and a quantitative phenotype based on the total Yale global motor and phonic tic severity scores (n\u2009=\u2009102). Both parametric and non\u2010parametric multipoint linkage analyses based on MCMC methods were performed using a 10\u2009cM spaced micro\u2010satellite autosomal marker set. Two regions of interest were identified under affecteds\u2010only recessive models; a LOD score of 3.3 on chromosome 1p for Yale tic severity and a LOD score of 3.1 on chromosome 3p for the TS1 phenotype. Twenty\u2010seven individuals shared linked segregating haplotypes for the 1p region. They had significantly higher Yale tic phonic scores than non\u2010sharers (<jats:italic>P<\/jats:italic>\u2009=\u20090.01). There were 46 haplotype sharers on chromosome 3p with significantly higher percentage of females among these individuals compared to the non\u2010sharers (<jats:italic>P<\/jats:italic>\u2009=\u20090.03). The significant linkage peaks on chromosomes 1p and 3p are in new areas of the genome for TS, and replication of these findings is necessary. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.31035","type":"journal-article","created":{"date-parts":[[2009,9,23]],"date-time":"2009-09-23T17:35:46Z","timestamp":1253727346000},"page":"656-662","source":"Crossref","is-referenced-by-count":18,"title":["Linkage analysis of Tourette syndrome in a large utah pedigree"],"prefix":"10.1002","volume":"153B","author":[{"given":"Stacey","family":"Knight","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary","family":"Coon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark 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