{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:57:33Z","timestamp":1790938653385,"version":"4.1.0"},"reference-count":68,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,10,22]],"date-time":"2009-10-22T00:00:00Z","timestamp":1256169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We performed a linkage analysis on 23 Finnish families with bipolar disorder and originating from the North\u2010Eastern region of Finland, using the Illumina Linkage Panel IV (6K) Array with an average intermarker spacing of 0.65\u2009cM across the genome. We detected genome\u2010wide significant evidence for linkage of mood disorder (bipolar disorder type I, II, or not otherwise specified, manic type of schizoaffective psychosis, cyclothymia, or recurrent depression) to chromosomes 7q31 (LOD\u2009=\u20093.20) and 9p13.1 (LOD\u2009=\u20094.02). Analyzing the best markers on the complete set of 179 Finnish bipolar families supported the findings on chromosome 9p13 (maximum LOD score of 3.02 at position 383\u2009Mb, immediately upstream of the centromere). This region harbors several interesting candidate genes, including contactin associated protein\u2010like 3 (<jats:italic>CNTNAP3<\/jats:italic>) and aldehyde dehydrogenase 1 (<jats:italic>ALDH1B1<\/jats:italic>). For the 7q31 locus, only one extended pedigree and ten families originating from the same late settlement region in North\u2010Eastern Finland provided evidence for linkage, suggesting that a gene predisposing to bipolar disorder is enriched in that region. Candidate genes of interest in this locus include potassium\u2010voltage\u2010gated channel, member 2 (<jats:italic>KCND2<\/jats:italic>) and calcium\u2010dependent activator protein for secretion 2 (<jats:italic>CADPS2<\/jats:italic>). The loci on the centromeric region of 9p13 and the telomeric region of 7q31 may represent susceptibility loci for mood disorder in the Finnish population. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.31039","type":"journal-article","created":{"date-parts":[[2009,10,22]],"date-time":"2009-10-22T16:13:11Z","timestamp":1256227991000},"page":"723-735","source":"Crossref","is-referenced-by-count":15,"title":["Identification of susceptibility loci at 7q31 and 9p13 for bipolar disorder in an isolated population"],"prefix":"10.1002","volume":"153B","author":[{"given":"Outi M.","family":"Palo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Soronen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaisa","family":"Silander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teppo","family":"Varilo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Tuononen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuula","family":"Kiesepp\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Partonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouko","family":"L\u00f6nnqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiina","family":"Paunio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Peltonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,10,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1995.03950140032004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/301844"},{"key":"e_1_2_6_4_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1987"},{"key":"e_1_2_6_5_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291706009627"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/3.9.2303"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000087122"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30524"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0888-7543(02)00040-X"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2005.030718"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041444-199524000-00005"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970531)74:3<254::AID-AJMG4>3.0.CO;2-Q"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.10.5604"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001104"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg199"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/424696"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069424"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.8.1265"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20112"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2156-6-S1-S82"},{"key":"e_1_2_6_23_1","first-page":"373","volume-title":"Manic\u2010depressive illness","author":"Goodwin FK","year":"1990"},{"key":"e_1_2_6_24_1","volume-title":"Manic\u2010depressive illness. 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