{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T16:48:40Z","timestamp":1773679720830,"version":"3.50.1"},"reference-count":65,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T00:00:00Z","timestamp":1259020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Genetic association studies have yielded extensive but frequently inconclusive data about genetic risk factors for schizophrenia. Clinical and genetic heterogeneity are possible factors explaining the inconsistent findings. The objective of this study was to test the association of commonly incriminated candidate genes with two clinically divergent subgroups, non\u2010deficit (SZ\u2010ND) and deficit\u2010schizophrenia (SZ\u2010D), and symptom severity, in order to test for replication of previously reported results. A homogeneous sample of 280 schizophrenia patients and 230 healthy controls of Hungarian, Caucasian descent were genotyped for polymorphisms in schizophrenia candidate genes <jats:italic>NRG1<\/jats:italic>, <jats:italic>DTNBP1<\/jats:italic>, <jats:italic>RGS4<\/jats:italic>, <jats:italic>G72<\/jats:italic>\/<jats:italic>G30<\/jats:italic>, and <jats:italic>PIP5K2A<\/jats:italic>. Patients were divided into the diagnostic subgroups of SZ\u2010ND and SZ\u2010D using the Schedule for Deficit Syndrome (SDS), and assessed clinically by the Positive and Negative Symptom Scale (PANSS). SNP8NRG241930 in <jats:italic>NRG1<\/jats:italic> and rs1011313 in <jats:italic>DTNBP1<\/jats:italic> were associated with SZ\u2010ND (<jats:italic>P<\/jats:italic>\u2009=\u20090.04 and 0.03, respectively). Polymorphisms in <jats:italic>RGS4<\/jats:italic>, <jats:italic>G72<\/jats:italic>\/<jats:italic>G30<\/jats:italic>, and <jats:italic>PIP5K2A<\/jats:italic> were neither associated with SZ\u2010ND nor with SZ\u2010D. SNP8NRG241930 showed association with the PANSS cognitive and hostility\/excitability factors, rs1011313 with the negative factor and SDS total score, and rs10917670 in <jats:italic>RGS4<\/jats:italic> was associated with the depression factor. Although these results replicate earlier findings about the genetic background of SZ\u2010ND and SZ\u2010D only partially, our data seem to confirm previously reported association of <jats:italic>NRG1<\/jats:italic> with schizophrenia without prominent negative symptoms. It was possible to detect associations of small\u2010to\u2010medium effect size between the investigated candidate genes and symptom severity. Such studies have the potential to unravel the possible connection between genetic and clinical heterogeneity in schizophrenia. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.31049","type":"journal-article","created":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T15:45:24Z","timestamp":1259077524000},"page":"792-801","source":"Crossref","is-referenced-by-count":46,"title":["Association study of <i>NRG1<\/i>, <i>DTNBP1<\/i>, <i>RGS4<\/i>, <i>G72<\/i>\/<i>G30<\/i>, and <i>PIP5K2A<\/i> with schizophrenia and symptom severity in a Hungarian sample"],"prefix":"10.1002","volume":"153B","author":[{"given":"J\u00e1nos M.","family":"R\u00e9thelyi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven C.","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia","family":"Polg\u00e1r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e1l","family":"Czobor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Strengman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter I.","family":"P\u00e1sztor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9 S.","family":"Kahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Bitter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,11,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.171"},{"key":"e_1_2_6_3_1","volume-title":"Diagnostic and statistical manual of mental disorders: DSM\u2010IV","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820080023004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001564"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2006.00234.x"},{"key":"e_1_2_6_7_1","first-page":"160","article-title":"The Hungarian version of the M.I.N.I. and the M.I.N.I. 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