{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:04:37Z","timestamp":1760983477779},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,4,5]],"date-time":"2010-04-05T00:00:00Z","timestamp":1270425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Essential tremor (ET) and Parkinson's disease (PD) are the most common movement disorders and show clinical, genetic, and pathophysiological overlap. Single\u2010nucleotide polymorphisms (SNPs) in the leucine\u2010rich repeat (LRR) and immunoglobulin (Ig) domain\u2010containing, Nogo receptor\u2010interacting protein gene (<jats:italic>LINGO1<\/jats:italic>) are associated with ET. <jats:italic>LINGO1<\/jats:italic> is overexpressed in the substantia nigra (SN) of PD patients and inhibition of LINGO1 confers neuroprotection in a rodent model of PD. In this study we test the hypothesis whether SNPs in the <jats:italic>LINGO1<\/jats:italic> gene that are associated with ET are also associated with PD. Three large German case\u2013control samples from Kiel, L\u00fcbeck, and T\u00fcbingen (total: 1,798 cases and 1,482 controls) were genotyped for the three <jats:italic>LINGO1<\/jats:italic> SNPs associated with ET. Association was assessed using allele\u2010 and genotype\u2010based tests in each of the three samples separately, in the combined sample, and in subsets of patients with early\u2010onset PD (&lt;50 years) and of patients with a positive family history of PD. Neither of the three samples alone nor the combined sample showed evidence for association between <jats:italic>LINGO1<\/jats:italic> SNPs and PD. The allele\u2010based test showed a trend toward nominal association for all three SNPs in the Kiel sample. The subsets with early\u2010onset PD or a positive family history did also not reveal evidence for association. SNPs in the <jats:italic>LINGO1<\/jats:italic> gene associated with ET could not be shown to be associated with PD in our study population, despite a postulated overlap between both diseases. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.31085","type":"journal-article","created":{"date-parts":[[2010,4,5]],"date-time":"2010-04-05T16:05:17Z","timestamp":1270483517000},"page":"1173-1178","source":"Crossref","is-referenced-by-count":18,"title":["<i>LINGO1<\/i> is not associated with Parkinson's disease in German 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