{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T17:38:07Z","timestamp":1722706687364},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T00:00:00Z","timestamp":1274918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We performed a case\u2013control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8\u2009Mb region on chromosome 6 (105\u2013113\u2009Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have<jats:italic>P<\/jats:italic>\u2010values of 2\u2009\u00d7\u200910<jats:sup>\u22125<\/jats:sup>). Both<jats:italic>P<\/jats:italic>\u2010values are in the top 5% of the distribution derived from null simulations (<jats:italic>P<\/jats:italic>\u2009=\u20090.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and\/or functional loci but found no further evidence of association with BP. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.31100","type":"journal-article","created":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T14:18:07Z","timestamp":1274969887000},"page":"1292-1297","source":"Crossref","is-referenced-by-count":5,"title":["An investigation of candidate regions for association with bipolar disorder"],"prefix":"10.1002","volume":"153B","author":[{"given":"Jo","family":"Knight","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanette S.","family":"Rochberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott F.","family":"Saccone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"John 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