{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T07:01:51Z","timestamp":1768028511027,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,9,22]],"date-time":"2010-09-22T00:00:00Z","timestamp":1285113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The insertion deletion (ins\/del) polymorphism of the serotonin transporter gene (5\u2010HTTLPR) has been associated with several psychiatric phenotypes and antidepressant's response. We investigated, in a large cohort of 5,608 controls and subjects suffering from various psychiatric disorders, the frequency of haplotypes and corresponding genotypes combining the 5\u2010HTTLPR and the other serotonin transporter promoter functional variant (rs25531). We showed that rs25531 lies 18\u2009bp 5\u2032 to the site where the 43\u2009bp (and not 44\u2009bp as previously described) ins\/del defines the 14\u2010 and 16\u2010repeat alleles. These polymorphisms should therefore be considered as four alleles instead of a triallelic unique locus. The very rare G\u201014\/G\u201016 genotype was carried on by only three subjects. These are women with a history of suicide attempt with a psychiatric history strongly suggesting a borderline personality disorder. Two of them have shown a non\u2010response to serotoninergic antidepressant. Interestingly, in one of them was observed a spectacular response after the introduction of bupropion. The genotyping droved our therapeutic approach, by preferring a dopaminergic over a serotoninergic agent. This study highlights the usefulness of studying very rare clinical cases as well as rare variants, in order to deal with the biological heterogeneity of spectral disorders. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.31118","type":"journal-article","created":{"date-parts":[[2010,9,22]],"date-time":"2010-09-22T17:45:33Z","timestamp":1285177533000},"page":"1494-1497","source":"Crossref","is-referenced-by-count":36,"title":["Rare genotype combination of the serotonin transporter gene associated with treatment response in severe personality disorder"],"prefix":"10.1002","volume":"153B","author":[{"given":"Nader","family":"Perroud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annick","family":"Salzmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar 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