{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:53:16Z","timestamp":1773269596083,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,10,18]],"date-time":"2010-10-18T00:00:00Z","timestamp":1287360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dysregulations of the hypothalamic\u2010pituitary\u2010adrenal (HPA) axis have been implicated in the pathogenesis of depressive disorders and the corticotropin\u2010releasing hormone (CRH) was found to modulate emotional memory consolidation. Recently, two studies have reported an interaction between childhood abuse and the TAT\u2013haplotype of the CRH\u2010Receptor Gene (<jats:italic>CRHR1<\/jats:italic>) connecting childhood adversities and genetic susceptibility to adult depression. We tested the hypothesis of an interaction of childhood maltreatment with single nucleotide polymorphisms (SNPs) and haplotypes of the<jats:italic>CRHR1<\/jats:italic>gene not previously investigated. Caucasian subjects (n\u2009=\u20091,638) from the German general population (Study of Health in Pomerania, SHIP) were analyzed. As in the previous studies, childhood abuse and neglect were assessed with the Childhood Trauma Questionnaire (CTQ) and depression with the Beck Depression Inventory (BDI\u20102). The<jats:italic>CRHR1<\/jats:italic>\u2010SNPs were genotyped on the Affymetrix Genome\u2010Wide Human SNP Array 6.0 platform. We identified an interaction between the TAT\u2013haplotype and childhood physical neglect. The interaction with physical neglect showed significant (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) results in 23 of the 28 SNPs, with rs17689882 (<jats:italic>P<\/jats:italic>\u2009=\u20090.0013) reaching \u201cgene\u2010wide\u201d significance. Although we did not replicate the specific interaction of abuse and the TAT\u2013haplotype of the<jats:italic>CRHR1<\/jats:italic>gene we confirmed the relevance of an interplay between variants within the<jats:italic>CRHR1<\/jats:italic>gene and childhood adversities in the modulation of depression in adults. The largest effect was found for rs17689882, a SNP previously not analyzed. Relevant sample differences between this and prior studies like lower BDI\u20102 scores, less childhood maltreatment and higher psychosocial functioning may account for the differences in gene\u2013environment interaction findings. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.31131","type":"journal-article","created":{"date-parts":[[2010,10,18]],"date-time":"2010-10-18T13:18:41Z","timestamp":1287407921000},"page":"1483-1493","source":"Crossref","is-referenced-by-count":92,"title":["Childhood maltreatment, the corticotropin\u2010releasing hormone receptor gene and adult depression in the general population"],"prefix":"10.1002","volume":"153B","author":[{"given":"Hans 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