{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:58:22Z","timestamp":1790794702690,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,11,2]],"date-time":"2010-11-02T00:00:00Z","timestamp":1288656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tourette syndrome (TS) is a childhood\u2010onset neuropsychiatric disorder that is familial and highly heritable. Although genetic influences are thought to play a significant role in the development of TS, no definite TS susceptibility genes have been identified to date. TS is believed to be genetically related to both obsessive\u2010compulsive disorder (OCD) and grooming disorders (GD) such as trichotillomania (TTM). SAP90\/PSD95\u2010associated protein 3 (<jats:italic>SAPAP3\/DLGAP3<\/jats:italic>) is a post\u2010synaptic scaffolding protein that is highly expressed in glutamatergic synapses in the striatum and has recently been investigated as a candidate gene in both OCD and GD studies. Given the shared familial relationship between TS, OCD and TTM, <jats:italic>DLGAP3<\/jats:italic> was evaluated as a candidate TS susceptibility gene. In a family\u2010based sample of 289 TS trios, 22 common single nucleotide polymorphisms (SNPs) in the <jats:italic>DLGAP3<\/jats:italic> region were analyzed. Nominally significant associations were identified between TS and rs11264126 and two haplotypes containing rs11264126 and rs12141243. Secondary analyses demonstrated that these results cannot be explained by the presence of comorbid OCD or TTM in the sample. Although none of these results remained significant after correction for multiple hypothesis testing, <jats:italic>DLGAP3<\/jats:italic> remains a promising candidate gene for TS. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.31134","type":"journal-article","created":{"date-parts":[[2010,11,3]],"date-time":"2010-11-03T00:50:30Z","timestamp":1288745430000},"page":"108-114","source":"Crossref","is-referenced-by-count":67,"title":["Family\u2010based genetic association study of <i>DLGAP3<\/i> in Tourette Syndrome"],"prefix":"10.1002","volume":"156","author":[{"given":"Jacquelyn","family":"Crane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesen","family":"Fagerness","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Osiecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyd","family":"Gunnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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