{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T08:49:22Z","timestamp":1769849362253,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,1,13]],"date-time":"2011-01-13T00:00:00Z","timestamp":1294876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Results of genome\u2010wide association studies (GWASs) for bipolar disorder (BD) have indicated <jats:italic>ANK3<\/jats:italic> as one of the most promising candidates for a susceptibility gene. In this study, we performed genetic association analysis of two single\u2010nucleotide polymorphisms (SNPs) in <jats:italic>ANK3<\/jats:italic> (rs1938526 and rs10994336), whose genome\u2010wide significant associations were reported in a previous meta\u2010analysis of GWASs, using genotyping data of Korean and Japanese case\u2013control samples and a part of data from a GWAS in Han\u2010Chinese from Taiwan. The total number of participants was 2,212 cases (352 from Korea, 860 from Japan, and 1,000 from Taiwan) and 2,244 controls (349 from Korea, 895 from Japan, and 1,000 from Taiwan). We could not detect any significant difference of allele frequency in individual analyses using each of the three populations. However, when we combined the three data sets and performed a meta\u2010analysis, rs1938526 showed nominally significant association (<jats:italic>P<\/jats:italic>\u2009=\u20090.048, odds ratio\u2009=\u20091.09). The over\u2010represented allele in BD was same as that reported in Caucasian GWASs. On the other hand, any significant association was not detected in rs10994336. This discrepancy between two SNPs may be explained by the different degree of linkage disequilibrium between Asian and Caucasian. These findings further supported the association between <jats:italic>ANK3<\/jats:italic> and BD, and also suggested the genomic region around rs1938526 as a common risk locus across ethnicities. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.31164","type":"journal-article","created":{"date-parts":[[2011,1,13]],"date-time":"2011-01-13T19:59:56Z","timestamp":1294948796000},"page":"312-315","source":"Crossref","is-referenced-by-count":30,"title":["Association of <i>ANK3<\/i> with bipolar disorder confirmed in East Asia"],"prefix":"10.1002","volume":"156","author":[{"given":"Atsushi","family":"Takata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Ozaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nakao","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kunugi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiya","family":"Inada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ujike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Min","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun\u2010Jeong","family":"Joo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo Yun","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigenobu","family":"Kanba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeo","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Sik","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadafumi","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4002012"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.3.1353"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.2009.00560.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.209"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1752"},{"issue":"2","key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/ajmg.b.31004","article-title":"Association analyses between brain\u2010expressed fatty\u2010acid binding protein (FABP) genes and schizophrenia and bipolar disorder","volume":"153","author":"Iwayama Y","year":"2010","journal-title":"Am J Med Genet Part B"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.628"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2004.02.007"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.5.2352"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2010.43"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/19.1.149"},{"key":"e_1_2_6_14_1","volume-title":"Review Manager (RevMan) [Computer program]. 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