{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:45:40Z","timestamp":1790376340272,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,4,7]],"date-time":"2011-04-07T00:00:00Z","timestamp":1302134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Late\u2010onset Alzheimer's disease (LOAD) is a multifactorial disease with the potential involvement of multiple genes. Four recent genome\u2010wide association studies (GWAS) have found variants showing significant association with LOAD on chromosomes 6, 10, 11, 12, 14, 18, 19, and on the X chromosome. We examined a total of 12 significant SNPs from these studies to determine if the results could be replicated in an independent large case\u2013control sample. We genotyped these 12 SNPs as well the <jats:italic>E2<\/jats:italic>\/<jats:italic>E3<\/jats:italic>\/<jats:italic>E4 APOE<\/jats:italic> polymorphisms in up to 993 Caucasian Americans with LOAD and up to 976 age\u2010matched healthy Caucasian Americans. We found no statistically significant associations between the 12 SNPs and the risk of AD. Stratification by <jats:italic>APOE*4<\/jats:italic> carrier status also failed to reveal statistically significant associations. Additional analyses were performed to examine potential associations between the 12 SNPs and age\u2010at\u2010onset (AAO) and disease duration among AD cases. Significant associations were observed between AAO and <jats:italic>ZNF224<\/jats:italic>\/rs3746319 (<jats:italic>P<\/jats:italic>\u2009=\u20090.002) and <jats:italic>KCNMA1<\/jats:italic>\/rs16934131 (<jats:italic>P<\/jats:italic>\u2009=\u20090.0066). <jats:italic>KCNMA1<\/jats:italic>\/rs16934131 also demonstrated statistically significant association with disease duration (<jats:italic>P<\/jats:italic>\u2009=\u20090.0002). Although we have been unable to replicate the reported GWAS association with AD risk in our sample, we have identified two new associations with AAO and disease duration that need to be confirmed in additional studies. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.31194","type":"journal-article","created":{"date-parts":[[2011,4,7]],"date-time":"2011-04-07T16:28:56Z","timestamp":1302193736000},"page":"507-512","source":"Crossref","is-referenced-by-count":17,"title":["Replication study of genome\u2010wide associated SNPs with late\u2010onset Alzheimer's disease"],"prefix":"10.1002","volume":"156","author":[{"given":"L.C.","family":"Burns","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.L.","family":"Minster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.Y.","family":"Demirci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.M.","family":"Barmada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ganguli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.L.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.T.","family":"DeKosky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.I.","family":"Kamboh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.12.008"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.10.008"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.305"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.2.168"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.440"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(94)05409-C"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001775"},{"key":"e_1_2_5_9_1","article-title":"Association of CLU and PICALM variants with Alzheimer's disease","author":"Kamboh MI","journal-title":"Neurobiol Aging"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.439"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/339815"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2009.95"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_2_5_14_1","volume-title":"R: A language and environment for statistical computing","author":"R Core Development Team","year":"2007"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.05.022"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300310"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401702101"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.574"}],"container-title":["American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.b.31194","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.31194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T14:45:31Z","timestamp":1700491531000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.b.31194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,7]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1002\/ajmg.b.31194"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.b.31194","archive":["Portico"],"relation":{},"ISSN":["1552-4841","1552-485X"],"issn-type":[{"value":"1552-4841","type":"print"},{"value":"1552-485X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,7]]}}}