{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:20:09Z","timestamp":1783484409582,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,5,11]],"date-time":"2011-05-11T00:00:00Z","timestamp":1305072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Major depression (MD) is often associated with disturbances of the hypothalamic\/pituitary\/thyroid (HPT) axis. Unfortunately, whether this association is secondary to common underlying genetic variation or whether the MD\u2010associated disturbances in HPT function are chronic or state\u2010dependent is unknown. To examine these questions, we genotyped 12 single nucleotide polymorphisms identified in previous genome wide association analyses of thyroid function in DNA contributed by 1,555 subjects from three longitudinal ethnically diverse studies that are well\u2010characterized for lifetime MD and thyroid function. We then examined associations between genetic variants and key outcomes of thyroid stimulating hormone, free thyroxine (FT4) and depression. We confirmed prior findings that two variants in <jats:italic>deiodinase 1<\/jats:italic> (<jats:italic>DIO1<\/jats:italic>), including a variant in the 3\u2032UTR of <jats:italic>DIO1<\/jats:italic> (rs11206244), were associated with altered FT4 levels in both White and African American subjects. We also found that rs11206244 genotype was associated with lifetime MD in White female subjects, in particular those from high\u2010risk cohorts. However, we found no association of current FT4 levels with lifetime MD in either ethnic group. We conclude that genetic variation influencing thyroid function is a risk factor for MD. Given the evidence from prior studies, further investigations of role of HPT variation in etiology and treatment of MD are indicated. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.31200","type":"journal-article","created":{"date-parts":[[2011,5,11]],"date-time":"2011-05-11T15:03:56Z","timestamp":1305126236000},"page":"593-599","source":"Crossref","is-referenced-by-count":33,"title":["The relationship of deiodinase 1 genotype and thyroid function to lifetime history of major depression in three independent populations"],"prefix":"10.1002","volume":"156","author":[{"given":"Robert A.","family":"Philibert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.H.","family":"Beach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy 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