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Individuals with ASD (970 families, 2,028 individuals) were recruited as part of the Autism Genome Project (AGP). The families were differentiated into families containing a female (either female\u2013female or male\u2013female) and those with only males. If the sex with the lower prevalence is associated with a greater genetic liability necessary to cross sex\u2010specific thresholds, the males from female containing families should be more severely affected than males from male only families. Affected subjects from the different types of families with ASD were sampled and compared on the social reciprocity and repetitive behavior scores from the Autism Diagnostic Interview\u2010Revised (ADI\u2010R). In general, females had lower repetitive behavior scores than males. More importantly, males from female containing families had higher repetitive behavior scores than males from male\u2013male families. No such differences were apparent on the social reciprocity scores. These results support the hypothesis of a multiple threshold model of genetic liability of ASD with females having a higher liability for affectation status, at least on the repetitive behavior dimension of the disorder. These data also support the dissociation of the different phenotypic dimensions of ASD in terms of its genetic architecture. The implications of these results for linkage and association studies are discussed. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.31238","type":"journal-article","created":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T07:58:58Z","timestamp":1321516738000},"page":"5-12","source":"Crossref","is-referenced-by-count":162,"title":["Sex differences in repetitive stereotyped behaviors in autism: Implications for genetic 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