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Here, we employed genome\u2010wide association (GWA) methods to discover novel genetic susceptibility loci associated with HAND, and validate susceptibility loci implicated in prior candidate gene studies. Data from 1,287 participants enrolled in the Multicenter AIDS Cohort Study between 1985 and 2010 were used. Genotyping was conducted with Illumina 1M, 1MDuo, or 550K platform. Linear mixed models determined subject\u2010specific slopes for change over time in processing speed and executive functioning, considering all visits including baseline and the most recent study visit. Covariates modeled as fixed effects included: time since the first visit, depression severity, nadir CD4+ T\u2010cell count, hepatitis C co\u2010infection, substance use, and antiretroviral medication regimen. Prevalence of HIV\u2010associated dementia (HAD) and neurocognitive impairment (NCI) was also examined as neurocognitive phenotypes in a case\u2013control analysis. No genetic susceptibility loci were associated with decline in processing speed or executive functioning among almost 2.5 million single nucleotide polymorphisms (SNPs) directly genotyped or imputed. No association between the SNPs and HAD or NCI were found. Previously reported associations between specific genetic susceptibility loci, HIV\u2010associated NCI, and HAD were not validated. In this first GWAS of HAND, no novel or previously identified genetic susceptibility loci were associated with any of the phenotypes examined. Due to the relatively small sample size, future collaborative efforts that incorporate this dataset may still yield important findings. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.32071","type":"journal-article","created":{"date-parts":[[2012,5,24]],"date-time":"2012-05-24T19:48:55Z","timestamp":1337888935000},"page":"669-683","source":"Crossref","is-referenced-by-count":28,"title":["Genome\u2010wide association study of neurocognitive impairment and dementia in HIV\u2010infected adults"],"prefix":"10.1002","volume":"159B","author":[{"given":"Andrew J.","family":"Levine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Service","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric N.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra 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