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We conducted univariate genome\u2010wide SNP (\u223c2.5 million) and gene\u2010based association analyses of these traits and examined the overlap in results across traits, including a prediction analysis of mood states using genetic polygenic scores for personality. Measures of neuroticism, extraversion, and symptoms of anxiety, depression, and general psychological distress were collected in eight European cohorts (n ranged 546\u20131,338; maximum total n\u2009=\u20096,268) whose mean age ranged from 55 to 79 years. Meta\u2010analysis of the cohort results was performed, with follow\u2010up associations of the top SNPs and genes investigated in independent cohorts (n\u2009=\u2009527\u20136,032). Suggestive association (<jats:italic>P<\/jats:italic>\u2009=\u20098\u2009\u00d7\u200910<jats:sup>\u22128<\/jats:sup>) of rs1079196 in the <jats:italic>FHIT<\/jats:italic> gene was observed with symptoms of anxiety. Other notable associations (<jats:italic>P<\/jats:italic>\u2009&lt;\u20096.09\u2009\u00d7\u200910<jats:sup>\u22126<\/jats:sup>) included SNPs in five genes for neuroticism (<jats:italic>LCE3C<\/jats:italic>, <jats:italic>POLR3A<\/jats:italic>, <jats:italic>LMAN1L<\/jats:italic>, <jats:italic>ULK3<\/jats:italic>, <jats:italic>SCAMP2<\/jats:italic>), <jats:italic>KIAA0802<\/jats:italic> for extraversion, and <jats:italic>NOS1<\/jats:italic> for general psychological distress. An association between symptoms of depression and rs7582472 (near to <jats:italic>MGAT5<\/jats:italic> and <jats:italic>NCKAP5<\/jats:italic>) was replicated in two independent samples, but other replication findings were less consistent. Gene\u2010based tests identified a significant locus on chromosome 15 (spanning five genes) associated with neuroticism which replicated (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in an independent cohort. Support for common genetic effects among personality and mood (particularly neuroticism and depressive symptoms) was found in terms of SNP association overlap and polygenic score prediction. The variance explained by individual SNPs was very small (up to 1%) confirming that there are no moderate\/large effects of common SNPs on personality and related traits. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.32072","type":"journal-article","created":{"date-parts":[[2012,5,24]],"date-time":"2012-05-24T19:50:21Z","timestamp":1337889021000},"page":"684-695","source":"Crossref","is-referenced-by-count":74,"title":["Genome\u2010wide association uncovers shared genetic effects among personality traits and mood states"],"prefix":"10.1002","volume":"159B","author":[{"given":"Michelle","family":"Luciano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer 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