{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:49:19Z","timestamp":1773301759924,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T00:00:00Z","timestamp":1350000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>DYX1C1 and<jats:italic>KIAA0319<\/jats:italic>have been two of the most extensively studied candidate genes for dyslexia given their important roles in the neuronal migration and neurite growth. The \u22123G\u2009&gt;\u2009A in<jats:italic>DYX1C1<\/jats:italic>and the 931C\u2009&gt;\u2009T in<jats:italic>KIAA0319<\/jats:italic>were of special interest for dyslexia but with inconsistent results. We performed a meta\u2010analysis integrating case\u2013control and transmission\/disequilibrium test (TDT) studies to clearly discern the effect of these two variants in dyslexia. Data from case\u2013control and TDT studies were analyzed in an allelic model using the Catmap software. In overall meta\u2010analysis, the pooled OR for the \u22123A allele and the 931T allele was 0.68 (95% CI\u2009=\u20090.25\u20131.87,<jats:italic>P<\/jats:italic><jats:sub>heterogeneity<\/jats:sub>\u2009=\u20090.000) and 0.87 (95% CI\u2009=\u20090.78\u20130.98,<jats:italic>P<\/jats:italic><jats:sub>heterogeneity<\/jats:sub>\u2009=\u20090.125), respectively. The stratified analysis showed that the between\u2010study heterogeneity regarding the \u22123G\u2009&gt;\u2009A polymorphism might be accounted by the publication year. Additionally, the sensitivity analysis of \u22123G\u2009&gt;\u2009A polymorphism indicated the stability of the result. In conclusion, our results suggested that the 931C\u2009&gt;\u2009T variant in<jats:italic>KIAA0319<\/jats:italic>, but not the \u22123G\u2009&gt;\u2009A in<jats:italic>DYX1C1<\/jats:italic>, was significantly associated with the risk of dyslexia. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.32102","type":"journal-article","created":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T13:58:28Z","timestamp":1350050308000},"page":"970-976","source":"Crossref","is-referenced-by-count":38,"title":["Genetic variant in<i>KIAA0319<\/i>, but not in<i>DYX1C1<\/i>, is associated with risk of dyslexia: An integrated 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