{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T14:35:38Z","timestamp":1771511738129,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,10,17]],"date-time":"2012-10-17T00:00:00Z","timestamp":1350432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To evaluate whether gene expression in chromosome 15q13\u2013q22.3 region is responsible for the development of Tourette syndrome (TS). Eighty\u2010four unrelated Chinese Han patients with TS (male\/female\u2009=\u200968\/16; mean age 9.92\u2009\u00b1\u20093.98 years) and 100 sex, age, and ethnicity matched normal controls (male\/female\u2009=\u200980\/20; mean age 10.90\u2009\u00b1\u20095.86 years) were enrolled in this study. We performed quantitative real\u2010time PCR on a subset of seven genes: the <jats:sc>L<\/jats:sc>\u2010histidine decarboxylase gene (<jats:italic>HDC<\/jats:italic>), the HECT domain and RCC\u20101 like domain 1 gene (<jats:italic>HERC1<\/jats:italic>), the HECT domain and RCC\u20101 like domain 2 gene (<jats:italic>HERC2<\/jats:italic>), the cholinergic receptor, neuronal nicotinic alpha polypeptide 7 gene (<jats:italic>CHRNA7<\/jats:italic>), the ubiquitin protein ligase E3A gene (<jats:italic>UBE3A<\/jats:italic>), the ubiquitin specific peptidase 3 gene (<jats:italic>USP3<\/jats:italic>) and the amyloid precursor protein\u2010binding protein A2 gene (<jats:italic>APBA2<\/jats:italic>) previously reported to be stably expressed in brain tissue. A significant difference was shown for the <jats:italic>APBA2<\/jats:italic> gene expression of peripheral lymphocytes between Chinese Han TS group and healthy controls (relative expression: 0.21\u2009\u00b1\u20090.16\u2010fold decrease in patients versus normal, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Indicating that the <jats:italic>APBA2<\/jats:italic> gene is a promising peripheral blood biomarker that discriminates between patients with TS and healthy subjects. Further studies into this gene and its protein products may provide insights into the pathogenesis of TS. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.32103","type":"journal-article","created":{"date-parts":[[2012,10,17]],"date-time":"2012-10-17T15:12:33Z","timestamp":1350486753000},"page":"977-980","source":"Crossref","is-referenced-by-count":5,"title":["Gene expression changes in peripheral blood from chinese han patients with tourette syndrome"],"prefix":"10.1002","volume":"159B","author":[{"given":"Jing","family":"Lei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linyan","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidong","family":"Le","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1116502"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890423349"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.107"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/YPG.0b013e32833511ce"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2007.02.015"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23618"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm323"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-198907000-00015"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738060210081001"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32003"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.10.160"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22504"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/303093"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2009.07.010"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5756-08.2009"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/YPG.0b013e3283060f6f"}],"container-title":["American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.b.32103","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.32103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T11:12:07Z","timestamp":1700565127000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.b.32103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,17]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1002\/ajmg.b.32103"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.b.32103","archive":["Portico"],"relation":{},"ISSN":["1552-4841","1552-485X"],"issn-type":[{"value":"1552-4841","type":"print"},{"value":"1552-485X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,17]]}}}