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Dyslexia susceptibility 1 candidate gene 1 (<jats:italic>DYX1C1<\/jats:italic>) on chromosome 15q21 was originally proposed as a candidate gene with two potentially functional polymorphisms at the \u22123G\/A and 1249G\/T positions showing association with RD. However, subsequent studies have yielded mixed results. We performed a literature review and meta\u2010analysis of the \u22123G\/A and 1249G\/T polymorphisms, including new unpublished data from two family\u2010based samples. Ten markers in <jats:italic>DYX1C1<\/jats:italic> were genotyped in the two independently ascertained samples. Single marker and \u22123G\/A:1249G\/T haplotype analyses were performed for RD in both samples, and quantitative trait analyses using standardized reading\u2010related measures was performed in one of the samples. For the meta\u2010analysis, we used a random\u2010effects model to summarize studies that tested for association between \u22123G\/A or 1249G\/T and RD. No significant association was found between the <jats:italic>DYX1C1<\/jats:italic> SNPs and RD or any of the reading\u2010related measures tested after correction for the number of tests performed. The previously reported risk haplotype (\u22123A:1249T) was not biased in transmission. A total of 9 and 10 study samples were included in the meta\u2010analysis of the \u22123G\/A and 1249G\/T polymorphisms, respectively. Neither polymorphism reached statistical significance, but the heterogeneity for the 1249G\/T polymorphism was high. The results of this study do not provide evidence for association between the putatively functional SNPs \u22123G\/A and 1249G\/T and RD. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.32123","type":"journal-article","created":{"date-parts":[[2013,1,22]],"date-time":"2013-01-22T15:36:36Z","timestamp":1358868996000},"page":"146-156","source":"Crossref","is-referenced-by-count":17,"title":["A family\u2010based association analysis and meta\u2010analysis of the reading disabilities candidate gene 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