{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:07:17Z","timestamp":1778814437035,"version":"3.51.4"},"reference-count":66,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T00:00:00Z","timestamp":1358380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Abnormal serotonergic pathways are implicated in numerous neuropsychiatric disorders including alcohol and drug dependence (abuse). The human 5\u2010hydroxytryptamine (serotonin) receptor 1B, encoded by the <jats:italic>HTR1B<\/jats:italic> (<jats:italic>5\u2010HT1B<\/jats:italic>) gene, is a presynaptic serotonin autoreceptor that plays an important role in regulating serotonin synthesis and release. Although there was evidence of associations of the <jats:italic>HTR1B<\/jats:italic> gene variants in the etiologies of substance use disorders, negative findings were also reported. To clarify the roles of commonly reported single nucleotide polymorphisms (SNPs) of the <jats:italic>HTR1B<\/jats:italic> gene underlying alcohol and drug dependence (abuse), we performed a meta\u2010analysis based on the available genotype data from individual candidate gene\u2010based association studies. Evidence of association was found between the functional SNP \u2212161A&gt;T (rs130058) and alcohol, cocaine, and heroin dependence (e.g., <jats:italic>P<\/jats:italic>\u2009=\u20090.03 and odds ratio (OR)\u2009=\u20091.2 (1.02, 1.42) in the combined European, Asian, African, and Hispanic populations). SNP \u2212261T&gt;G (rs11568817) also showed evidence of association but with different directions in Europeans and non\u2010Europeans (e.g., <jats:italic>P<\/jats:italic>\u2009=\u20090.0018 with OR\u2009=\u20091.42 (1.14, 1.76) and <jats:italic>P<\/jats:italic>\u2009=\u20090.01 with ORs\u2009=\u20090.5 (0.3, 0.85), respectively). This meta\u2010analysis supports the associations of <jats:italic>HTR1B<\/jats:italic> \u2212261T&gt;G and \u2212161A&gt;T with alcohol and drug abuse and further investigations are warranted in larger samples. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.32128","type":"journal-article","created":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T13:57:17Z","timestamp":1358431037000},"page":"169-176","source":"Crossref","is-referenced-by-count":53,"title":["Associations of the 5\u2010hydroxytryptamine (serotonin) Receptor 1B gene (<i>HTR1B<\/i>) with alcohol, cocaine, and heroin abuse"],"prefix":"10.1002","volume":"162","author":[{"given":"Jian","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"LaRocque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(98)80038-5"},{"key":"e_1_2_7_3_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders (DSM)","author":"American Psychiatric Association"},{"key":"e_1_2_7_4_1","volume-title":"The neurobiological basis of suicide","author":"Bach H","year":"2012"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(99)00010-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1997.tb52356.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.12.039"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2005-6-9-r75"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1770"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000065140"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2011.72.752"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1473"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2011.09.020"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0996-98"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.bbr.2012.08.048","article-title":"A novel highly selective 5\u2010HT(6) receptor antagonist attenuates ethanol and nicotine seeking but does not affect inhibitory response control in Wistar rats","volume":"236","author":"de Bruin NM","year":"2012","journal-title":"Behav Brain Res"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.23.120189.000315"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001403"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg055"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(02)00353-2"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00455.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.130"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.12.1125"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.07.114"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-009-0701-2"},{"issue":"5","key":"e_1_2_7_28_1","first-page":"369","article-title":"5\u2010HT1A receptor and 5\u2010HT1B receptor knockout mice in stress and anxiety paradigms","volume":"14","author":"Groenink L","year":"2003","journal-title":"Behav Pharmacol"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.21608"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10865-012-9452-y"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007020200042"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041444-200209000-00005"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2000.tb04618.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(99)00030-5"},{"issue":"1","key":"e_1_2_7_35_1","first-page":"13","article-title":"Codon usage and tRNA content in unicellular and multicellular organisms","volume":"2","author":"Ikemura T","year":"1985","journal-title":"Mol Biol Evol"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.11.1313"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2009.00990.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001890"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl122"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl152"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.02.024"},{"key":"e_1_2_7_42_1","article-title":"Modification of the behavioral effects of morphine in rats by serotonin (5\u2010HT)(1A) and 5\u2010HT (2A) receptor agonists: Antinociception, drug discrimination, and locomotor activity","author":"Li JX","year":"2012","journal-title":"Psychopharmacology (Berl)"},{"issue":"14","key":"e_1_2_7_43_1","doi-asserted-by":"crossref","first-page":"6157","DOI":"10.1523\/JNEUROSCI.19-14-06157.1999","article-title":"5\u2010HT1B receptor knock\u2010out mice exhibit increased exploratory activity and enhanced spatial memory performance in the Morris water maze","volume":"19","author":"Malleret G","year":"1999","journal-title":"J Neurosci"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(11)70695-8"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.12.033"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00581-1"},{"key":"e_1_2_7_47_1","volume-title":"Use and Dependence, State and Federal Prisoners, 2004","author":"Mumola CJ","year":"2006"},{"issue":"23","key":"e_1_2_7_48_1","doi-asserted-by":"crossref","first-page":"10078","DOI":"10.1523\/JNEUROSCI.18-23-10078.1998","article-title":"Serotonin1B receptor stimulation enhances cocaine reinforcement","volume":"18","author":"Parsons LH","year":"1998","journal-title":"J Neurosci"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.03.024"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fpc.0000182782.87932.d6"},{"issue":"1","key":"e_1_2_7_51_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.33549\/physiolres.931903","article-title":"Serotonin receptors\u2014From molecular biology to clinical applications","volume":"60","author":"Pytliak M","year":"2011","journal-title":"Physiol Res"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/30259"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1080\/13556210050003757"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(92)90026-3"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-9-119"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01366-X"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.56.7.655"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1441.018"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.2174\/157015911795017137"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2012.08.025"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-9081-8-18"},{"key":"e_1_2_7_62_1","volume-title":"World Health Organization's International Statistical Classification of Diseases and Related Health Problems (ICD)","author":"World Health Organization"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1955.tb01348.x"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2008.02243.x"},{"issue":"3","key":"e_1_2_7_65_1","first-page":"229","article-title":"Association between heroin dependence and the polymorphism of 5\u2010hydroxytryptamine receptor gene","volume":"14","author":"Yuan C","year":"2005","journal-title":"Chin J Behav Med Sci"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.11090210"},{"issue":"2","key":"e_1_2_7_67_1","doi-asserted-by":"crossref","first-page":"52S","DOI":"10.1016\/S0893-133X(99)00047-0","article-title":"Altered emotional states in knockout mice lacking 5\u2010HT1A or 5\u2010HT1B receptors","volume":"21","author":"Zhuang X","year":"1999","journal-title":"Neuropsychopharmacology"}],"container-title":["American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.b.32128","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.32128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T19:01:37Z","timestamp":1697050897000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.b.32128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,17]]},"references-count":66,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1002\/ajmg.b.32128"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.b.32128","archive":["Portico"],"relation":{},"ISSN":["1552-4841","1552-485X"],"issn-type":[{"value":"1552-4841","type":"print"},{"value":"1552-485X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,17]]}}}