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Although several genes are known to play a role in early\u2010onset AD, identification of the genetic basis of late onset AD (LOAD) has been challenging, with only the <jats:italic>APOE<\/jats:italic> gene known to have a high contribution to both AD risk and age\u2010at\u2010onset. Here, we present the first genome\u2010scan analysis of the complete, well\u2010characterized University of Washington LOAD sample of 119 pedigrees, using age\u2010at\u2010onset as the trait of interest. The analysis approach used allows for a multilocus trait model while at the same time accommodating age censoring, effects of <jats:italic>APOE<\/jats:italic> as a known genetic covariate, and full pedigree and marker information. The results provide strong evidence for linkage of loci contributing to age\u2010at\u2010onset to genomic regions on chromosome 6q16.3, and to 19q13.42 in the region of the <jats:italic>APOE<\/jats:italic> locus. There was evidence for interaction between <jats:italic>APOE<\/jats:italic> and the locus on chromosome 6q and suggestive evidence for linkage to chromosomes 11p13, 15q12\u201014, and 19p13.12. These results provide the first independent confirmation of an AD age\u2010at\u2010onset locus on chromosome 6 and suggest that further efforts towards identifying the underlying causal locus or loci are warranted. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.32133","type":"journal-article","created":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T15:04:43Z","timestamp":1359126283000},"page":"201-212","source":"Crossref","is-referenced-by-count":5,"title":["Genome scan in familial late\u2010onset Alzheimer's disease: A locus on chromosome 6 contributes to age\u2010at\u2010onset"],"prefix":"10.1002","volume":"162","author":[{"given":"Wei","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth E.","family":"Marchani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles Y.K.","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen J.","family":"Steinbart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard D.","family":"Schellenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas D.","family":"Bird","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen M.","family":"Wijsman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,25]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Alzheimer's Association.2010.2010 Alzheimer's Disease Facts and Figures. 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