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We examined a particular diathesis\u2010stress model for SAD in which we included a functional polymorphism of the serotonin transporter (5\u2010HTTLPR) as a genetic vulnerability factor and childhood emotional maltreatment (CEM) as an environmental stressor. Current analyses were based on individuals who participated in the Study of Health in Pomerania. Psychiatric disorders were assessed with diagnostic interviews according to DSM\u2010IV criteria. The triallelic genotype of 5\u2010HTTLPR was determined. Statistical analyses were performed in 78 individuals with SAD and 1,035 without an axis I disorder. Logistic regression analysis revealed that the experience of CEM (odds ratio [OR] 4.56; 95% confidence interval [CI] 2.65\u20137.84), the l\/l genotype of 5\u2010HTTLPR (OR 2.13; 95% CI 1.31\u20133.48), female gender (OR 3.03; 95% CI 1.80\u20135.08) and younger age (OR 1.04; 95% CI 1.02\u20131.06) increased the odds for SAD. The data suggest that CEM, the l\/l genotype of 5\u2010HTTLPR, female gender and younger age are risk factors for SAD. This is in favor of the tested diathesis\u2010stress model. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.32142","type":"journal-article","created":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T15:24:15Z","timestamp":1362756255000},"page":"253-261","source":"Crossref","is-referenced-by-count":26,"title":["Testing the diathesis\u2010stress model: 5\u2010HTTLPR, childhood emotional maltreatment, and vulnerability to social anxiety 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