{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:04:46Z","timestamp":1769155486960,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T00:00:00Z","timestamp":1390521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Alzheimer's disease (AD) is the most common neurodegenerative disorder characterized by the accumulation of amyloid beta (A\u03b2) plaques and Tau\u2010containing neurofibrillary tangles in vulnerable brain areas. The progression of AD is well correlated with hippocampal neuron loss which highly suggests genes associated with neuron survival would be important for AD pathogenesis. According to the recent results of genome\u2010wide association studies (GWAS) and other reported studies, we selected two single nucleotide polymorphisms (SNPs), rs3765728 within tumor protein p73 (<jats:italic>P73<\/jats:italic>), and rs34011 within fibroblast growth factor 1 (<jats:italic>FGF1<\/jats:italic>), both genes were related to neuron survival. We analyzed the distribution of rs3765728 and rs34011 in 1,083 Chinese subjects including 429 unrelated sporadic AD patients and 654 unrelated age and gender\u2010matched control subjects. We found that the genotype distribution of rs34011 was significantly different between AD and control group (\u03c7<jats:sup>2<\/jats:sup>\u2009=\u20099.048, df\u2009=\u20092,<jats:italic>P<\/jats:italic>\u2009=\u20090.011). Logistic regression manifested the risk of AD increased in TT genotype carriers in total subjects (Wald\u2009=\u20098.892, df\u2009=\u20091,<jats:italic>P<\/jats:italic>\u2009=\u20090.003, odds ratio [OR]:2.009, 95% confidence interval [95%CI]: 1.270\u20133.178). This effect was also found in<jats:italic>APOE<\/jats:italic>\u03f54 carrier group (Wald\u2009=\u20097.844, df\u2009=\u20091,<jats:italic>P<\/jats:italic>\u2009=\u20090.005, OR: 4.201, 95%CI: 1.539\u201311.472), suggesting the rs34011 has a synergetic effect of<jats:italic>APOE<\/jats:italic>on AD risk. However, no association was observed between rs3765728 and AD in the Han Chinese population (\u03c7<jats:sup>2<\/jats:sup>\u2009=\u20090.431, df\u2009=\u20092,<jats:italic>P<\/jats:italic>\u2009=\u20090.806). \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.b.32205","type":"journal-article","created":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T15:59:34Z","timestamp":1390579174000},"page":"131-136","source":"Crossref","is-referenced-by-count":12,"title":["A variant within<i>FGF1<\/i>is associated with Alzheimer's disease in the Han Chinese population"],"prefix":"10.1002","volume":"165","author":[{"given":"Qing\u2010Qing","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Neurology and Institute of Neurology Huashan Hospital, Shanghai Medical College, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Min","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology Huashan Hospital, Shanghai Medical College, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology Huashan Hospital, Shanghai Medical College, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology Huashan Hospital, Shanghai Medical College, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology Huashan Hospital, Shanghai Medical College, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Lei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology Huashan Hospital, Shanghai Medical College, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shen\u2010Ji","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology Huashan Hospital, Shanghai Medical College, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Ying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology Huashan Hospital, Shanghai Medical College, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.272427"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2494"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.03.018"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.04.010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","unstructured":"ChouliarasL SierksmaAS KenisG PrickaertsJ LemmensMA BrasnjevicI van DonkelaarEL Martinez\u2010MartinezP LosenM De BaetsMH KholodN van LeeuwenF HofPR van OsJ SteinbuschHW van den HoveDL RuttenBP.2010. 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