{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:25:24Z","timestamp":1786976724797,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,16]],"date-time":"2013-11-16T00:00:00Z","timestamp":1384560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      This comprehensive meta\u2010analysis was applied to case\u2010control studies of the association between PD and\n                      <jats:italic>GBA<\/jats:italic>\n                      to assess the joint evidence for the association, the influence of individual studies, and evidence for publication bias. We searched PubMed, Medline, Cochrane Library, reference lists of relevant studies to June 2012, and email contact with authors. For the case\u2010control studies, the authors found 1) support for the association between PD and\n                      <jats:italic>GBA<\/jats:italic>\n                      , both in total group analysis [fixed: OR and 95%CI: 4.825 (3.901\u20135.968),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001; random: OR and 95%CI: 4.791 (3.520\u20136.520),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001] and in Asia, Europe, Americas, and Israel subgroups analysis [Asia: fixed: OR and 95%CI: 7.495 (4.490\u201312.511),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001, random: OR and 95%CI: 7.989 (4.060\u201315.723),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001; Americas: fixed: OR and 95%CI: 4.036 (2.460\u20136.622),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001, random: OR and 95%CI: 4.065 (2.464\u20136.707),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001; Europe: fixed: OR and 95%CI: 3.353 (2.287\u20134.917),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001, random: OR and 95%CI: 3.559 (2.148\u20135.894),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001; Israel: fixed\/random: OR and 95%CI: 6.430 (4.430\u20139.333),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001], 2) no evidence that this association was accounted for by any one study, and 3) no evidence for publication bias. In conclusion,\n                      <jats:italic>GBA<\/jats:italic>\n                      mutation status may be significantly associated with PD. \u00a9 2013 Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajmg.b.32214","type":"journal-article","created":{"date-parts":[[2013,11,16]],"date-time":"2013-11-16T05:28:04Z","timestamp":1384579684000},"page":"96-102","source":"Crossref","is-referenced-by-count":10,"title":["Significant study of population stratification, sensitivity analysis and trim and fill analyses on\n                    <i>GBA<\/i>\n                    mutation and parkinson's disease"],"prefix":"10.1002","volume":"165","author":[{"given":"Jie","family":"Liu","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese\u2010Western Medicine Shanghai Institute of Orthopaedics and Traumatology Department of Orthopaedics Shanghai Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Genomics, Research center for experimental medicine Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 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