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Our sample consisted of 110 proband cases with HP and 48 controls without HP, plus 128 first\u2010degree case relatives and 50 first\u2010degree control relatives. Case versus control relatives had higher recurrence risk estimates for both HP and OCD but not SP. The finding that HP is familial is consistent with the only existing twin study. Additional analyses suggest that there may be a familial subtype of HP with comorbid OCD. Those adult proband cases with HP\u2009+\u2009OCD had more anxiety and depression than cases without OCD. Probands with HP\u2009+\u2009OCD also had earlier onset of OCD. Identification of an HP subtype with comorbid OCD may have significant theoretical and treatment implications. The data did not provide evidence for an etiologic relationship between HP and SP. Replication of these findings in future studies with larger cohorts of case and control relatives is warranted. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.b.32218","type":"journal-article","created":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T17:45:18Z","timestamp":1389375918000},"page":"167-174","source":"Crossref","is-referenced-by-count":41,"title":["A family study of trichotillomania and chronic hair pulling"],"prefix":"10.1002","volume":"165","author":[{"given":"Nancy J.","family":"Keuthen","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital\/Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin M.","family":"Altenburger","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital\/Harvard Medical School Boston 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