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We assessed symptoms of obsessive\u2010compulsive disorder, body dysmorphic disorder, hoarding disorder, hypochondriasis, panic disorder, social phobia and generalized anxiety disorder in 2,495 adult twins (1,468 female). Prevalence estimates for the corresponding symptom measures were determined using empirically derived cut\u2010off scores. Twin resemblance was assessed by Pearson correlations and biometrical model\u2010fitting analyses, incorporating sex\u2010specific effects, using OpenMx. Prevalence estimates ranged from 1.6% in the symptoms of generalized anxiety to 16.9% for social phobia. Female twins demonstrated significantly higher prevalence rates across all domains with the exception of obsessive\u2010compulsive symptoms. Additive genetic factors accounted for a moderate proportion of the total liability to each symptom domain. Evidence suggesting qualitative genetic sex differences (i.e., distinct genetic influences between genders) was observed for body dysmorphic concern and panic symptoms, while quantitative differences were observed for hoarding and social phobia symptoms, indicating stronger heritability in females. Novel findings in this study include the observation of probable genetic sex differences in liability towards hoarding symptoms and dysmorphic concern, as well as the lack of such differences in hypochondriasis. The trend towards qualitative sex differences in panic symptoms has some intuitive appeal with regard to biological\u2010experimental models of panic. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.b.32233","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T07:53:10Z","timestamp":1398239590000},"page":"314-325","source":"Crossref","is-referenced-by-count":40,"title":["Prevalence and heritability of obsessive\u2010compulsive spectrum and anxiety disorder symptoms: A survey of the Australian Twin Registry"],"prefix":"10.1002","volume":"165","author":[{"given":"Clara","family":"L\u00f3pez\u2010Sol\u00e0","sequence":"first","affiliation":[{"name":"Bellvitge Biomedical Research Institute\u2010IDIBELL Department of Psychiatry Hospital de Bellvitge Barcelona Spain"},{"name":"Department of Clinical Sciences Bellvitge Campus University of Barcelona Barcelona Spain"},{"name":"CIBERSAM (Centro de Investigaci\u00f3n en Red de 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