{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:50:05Z","timestamp":1791298205569,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T00:00:00Z","timestamp":1403654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002066","name":"GlaxoSmithKline foundation","doi-asserted-by":"publisher","award":["G0701420"],"award-info":[{"award-number":["G0701420"]}],"id":[{"id":"10.13039\/501100002066","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute for Health Research (NIHR) Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Kings College London"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:label\/><jats:p>Epidemiological studies have recognized a genetic diathesis for suicidal behavior, which is independent of other psychiatric disorders. Genome\u2010wide association studies (GWAS) on suicide attempt (SA) and ideation have failed to identify specific genetic variants. Here, we conduct further GWAS and for the first time, use polygenic score analysis in cohorts of patients with mood disorders, to test for common genetic variants for mood disorders and suicide phenotypes. Genome\u2010wide studies for SA were conducted in the RADIANT and GSK\u2010Munich recurrent depression samples and London Bipolar Affective Disorder Case\u2010Control Study (BACCs) then meta\u2010analysis was performed. A GWAS on suicidal ideation during antidepressant treatment had previously been conducted in the Genome Based Therapeutic Drugs for Depression (GENDEP) study. We derived polygenic scores from each sample and tested their ability to predict SA in the mood disorder cohorts or ideation status in the GENDEP study. Polygenic scores for major depressive disorder, bipolar disorder and schizophrenia from the Psychiatric Genomics Consortium were used to investigate pleiotropy between psychiatric disorders and suicide phenotypes. No significant evidence for association was detected at any SNP in GWAS or meta\u2010analysis. Polygenic scores for major depressive disorder significantly predicted suicidal ideation in the GENDEP pharmacogenetics study and also predicted SA in a combined validation dataset. Polygenic scores for SA showed no predictive ability for suicidal ideation. Polygenic score analysis suggests pleiotropy between psychiatric disorders and suicidal ideation whereas the tendency to <jats:italic>act<\/jats:italic> on such thoughts may have a partially independent genetic diathesis. \u00a9 2014 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.b.32247","type":"journal-article","created":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T08:43:11Z","timestamp":1403685791000},"page":"428-437","source":"Crossref","is-referenced-by-count":116,"title":["Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: A genome\u2010wide association and polygenic scoring study"],"prefix":"10.1002","volume":"165","author":[{"given":"Niamh","family":"Mullins","sequence":"first","affiliation":[{"name":"MRC Social, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, King's College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader","family":"Perroud","sequence":"additional","affiliation":[{"name":"Psychiatry University Hospital of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Uher","sequence":"additional","affiliation":[{"name":"MRC Social, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, King's College London London United Kingdom"},{"name":"Department of Psychiatry Dalhousie University Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy W.","family":"Butler","sequence":"additional","affiliation":[{"name":"MRC Social, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, King's College London London United Kingdom"},{"name":"Department of Psychiatry University of Hong Kong Hong Kong, Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Cohen\u2010Woods","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Adelaide Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Rivera","sequence":"additional","affiliation":[{"name":"MRC Social, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, King's College London London United Kingdom"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental CIBERSAM, University of Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Malki","sequence":"additional","affiliation":[{"name":"MRC Social, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, King's College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Euesden","sequence":"additional","affiliation":[{"name":"MRC Social, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, King's College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Power","sequence":"additional","affiliation":[{"name":"MRC Social, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, King's College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine E.","family":"Tansey","sequence":"additional","affiliation":[{"name":"MRC Centre for Neuropsychiatric Genetics and Genomics Neuroscience and Mental Health Research Institute, Cardiff University Cardiff United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Clinical and Experimental Medicine, University of Birmingham Birmingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Jones","sequence":"additional","affiliation":[{"name":"MRC Centre for Neuropsychiatric Genetics and Genomics Neuroscience and Mental Health Research Institute, Cardiff University Cardiff United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Craddock","sequence":"additional","affiliation":[{"name":"MRC Centre for Neuropsychiatric Genetics and Genomics Neuroscience and Mental Health Research Institute, Cardiff University Cardiff United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Owen","sequence":"additional","affiliation":[{"name":"MRC Centre for Neuropsychiatric Genetics and Genomics Neuroscience and Mental Health Research Institute, Cardiff University Cardiff United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ania","family":"Korszun","sequence":"additional","affiliation":[{"name":"Barts and The London Medical School Queen Mary University of London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Trinity Centre for Health Science Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Mors","sequence":"additional","affiliation":[{"name":"Research Department P Aarhus University Hospital Risskov Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Preisig","sequence":"additional","affiliation":[{"name":"University Hospital Center and University of Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Maier","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella","family":"Rietschel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Bonn Bonn Germany"},{"name":"Division of Genetic Epidemiology in Psychiatry Central Institute of Mental Health Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Rice","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University, St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertram","family":"M\u00fcller\u2010Myhsok","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Psychiatry Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth B.","family":"Binder","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Psychiatry Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Lucae","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Psychiatry Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Ising","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Psychiatry Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian W.","family":"Craig","sequence":"additional","affiliation":[{"name":"MRC Social, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, King's College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E.","family":"Farmer","sequence":"additional","affiliation":[{"name":"MRC Social, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, King's College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"McGuffin","sequence":"additional","affiliation":[{"name":"MRC Social, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, King's College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerome","family":"Breen","sequence":"additional","affiliation":[{"name":"MRC Social, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, King's College London London United Kingdom"},{"name":"NIHR Biomedical Research Centre for Mental Health South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathryn M.","family":"Lewis","sequence":"additional","affiliation":[{"name":"MRC Social, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, King's College London London United Kingdom"},{"name":"Division of Genetics and Molecular Medicine King's College London School of Medicine, Guy's Hospital London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890423349"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.153.8.1009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1961.01710120031004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2005.02.010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1996.01830120085015"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.31127"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp051"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1034"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003348"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20297"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1985.03360070053022"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3472"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-4-42"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021055617738"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2011.597875"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30906"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000127416.92128.B0"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1998.tb09957.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32832e4bcd"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.09091380"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61766-8"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.21"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.2.181"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810320088015"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.131"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/78.3.691"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300998"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.10040541"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-7-60"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2010.70"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.943"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/19.1.149"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08185"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2011.06.002"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(00)00275-5"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.940"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020690"},{"key":"e_1_2_6_42_1","first-page":"277","volume-title":"Origin, prevention and treatment of affective disorders","author":"Schulsinger F","year":"1979"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2008.01328.x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.10.004"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32210"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2001.30608.x"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.09070932"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-007-0823-2"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.4"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.05.014"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810180089012"},{"key":"e_1_2_6_52_1","volume-title":"Diagnosis and Clinical Measurement in Psychiatry. A reference manual for SCAN","author":"World Health Organisation","year":"1998"},{"key":"e_1_2_6_53_1","unstructured":"World Health Organisation.2005.Suicide Prevention (SUPRE) [Online]. Available:http:\/\/www.who.int\/mental_health\/prevention\/suicide[Accessed January 4 2012.]"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.6665407"}],"container-title":["American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.b.32247","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.32247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T16:38:36Z","timestamp":1696610316000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.b.32247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,25]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1002\/ajmg.b.32247"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.b.32247","archive":["Portico"],"relation":{},"ISSN":["1552-4841","1552-485X"],"issn-type":[{"value":"1552-4841","type":"print"},{"value":"1552-485X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,25]]}}}