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We performed genome\u2010wide screening for copy number variations (CNVs) in 10 large Indian dyslexic families using Affymetrix Genome\u2010Wide Human SNP Array 6.0. Results revealed the complex genomic rearrangements due to one non\u2010contiguous deletion and five contiguous micro duplications and micro deletions at 17q21.31 region in three dyslexic families. CNVs in this region harbor the genes KIAA1267, LRRC37A, ARL17A\/B, NSFP1, and NSF. The CNVs in case 1 and case 2 at this locus were found to be in homozygous state and case 3 was a de novo CNV. These CNVs were found with at least one CNV having a common break and end points in the parents. This cluster of genes containing NSF is implicated in learning, cognition, and memory, though not formally associated with dyslexia. Molecular network analysis of these and other dyslexia related module genes suggests <jats:italic>NSF<\/jats:italic> and other genes to be associated with cellular\/vesicular membrane fusion and synaptic transmission. Thus, we suggest that <jats:italic>NSF<\/jats:italic> in this cluster would be the nearest gene responsible for the learning disability phenotype. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.b.32260","type":"journal-article","created":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T10:08:56Z","timestamp":1408442936000},"page":"572-580","source":"Crossref","is-referenced-by-count":15,"title":["Family based genome\u2010wide copy number scan identifies complex rearrangements at 17q21.31 in dyslexics"],"prefix":"10.1002","volume":"165","author":[{"given":"Avinash M.","family":"Veerappa","sequence":"first","affiliation":[{"name":"Genetics and Genomics Laboratory Department of Studies in Zoology University of Mysore Manasagangotri Mysore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marita","family":"Saldanha","sequence":"additional","affiliation":[{"name":"Department of Studies in Psychology University of Mysore Manasagangotri Mysore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakash","family":"Padakannaya","sequence":"additional","affiliation":[{"name":"Department of Studies in Psychology University of Mysore Manasagangotri Mysore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nallur B.","family":"Ramachandra","sequence":"additional","affiliation":[{"name":"Genetics and Genomics Laboratory Department of Studies in Zoology University of Mysore Manasagangotri Mysore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,19]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Affymetrix Inc.Data Sheet: Genome Wide Human SNP Array 6.0 (2009)."},{"key":"e_1_2_6_3_1","unstructured":"Affymetrix Inc.Technical Note: Guide to Probe Logarithmic Intensity Error (PLIER) Estimation (2005)."},{"key":"e_1_2_6_4_1","unstructured":"Affymetrix Inc.User manual: Genotyping Console\u2122 Software 2.1 (2008)."},{"key":"e_1_2_6_5_1","unstructured":"Affymetrix Inc.White Paper: BRLMM\u2010P: A Genotype Calling Method for the SNP Array 5.0 (2007)."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04489"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2007.09.005"},{"key":"e_1_2_6_8_1","unstructured":"Birdsuite.AlgorithmHttp:\/\/www.broad.mit.edu\/mpg\/birdsuite\/birdseed.html2010."},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08689"},{"key":"e_1_2_6_10_1","unstructured":"Bozeman MT: Golden Helix Inc.SNP & Variation Suite (Version 7.x) [Software]. 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