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Recent advances in human molecular research have revealed that alterations in the histone deacetylase 4 gene (<jats:italic>HDAC4<\/jats:italic>) are responsible for the clinical manifestations of BDMR. Here, we report two male patients with 2q37.3 deletions. One of the patients showed a typical BDMR phenotype, and <jats:italic>HDAC4<\/jats:italic> was included in the deletion region. <jats:italic>HDAC4<\/jats:italic> was preserved in the other patient, and he showed a normal intelligence level with the delayed learning of complex motor skills. Detailed neuropsychological examinations revealed similar neuropsychological profiles in these two patients (visuo\u2010spatial dyspraxia) that suggested developmental dyspraxia. These observations suggested that some other candidate genes for neuronal development exist in the telomeric region of <jats:italic>HDAC4<\/jats:italic>. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.b.32274","type":"journal-article","created":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T07:33:35Z","timestamp":1413790415000},"page":"684-690","source":"Crossref","is-referenced-by-count":11,"title":["Neuropsychological profiles of patients with 2q37.3 deletion associated with developmental dyspraxia"],"prefix":"10.1002","volume":"165","author":[{"given":"Kaeko","family":"Ogura","sequence":"first","affiliation":[{"name":"Department of Rehabilitation for Brain Functions Developmental Disability Study Section Research Institute of National Rehabilitation Center for Persons with Disabilities Tokorozawa Japan"},{"name":"Department of Behavioral Neurology and Cognitive Neuroscience Tohoku University Graduate School of Medicine Sendai 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