{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:54:44Z","timestamp":1793040884661,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T00:00:00Z","timestamp":1423094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:label\/><jats:p>MicroRNAs (miRNA, miR) have been implicated as promising blood\u2010based biomarkers for schizophrenia patients. This study aimed to clinically validate miRNA as potential schizophrenia biomarkers. Plasma levels of 10 miRNAs were analyzed using qPCR in a cohort of 61 schizophrenia patients and 62 normal controls, as well as 25 patients particularly selected for a six\u2010week antipsychotic treatment course. Positive And Negative Syndrome Scale (PANSS), Global Assessment Scale (GAS) and Clinical Global Impression (CGI) were administered to assess the clinical symptoms. The results demonstrated that a panel of miRNAs consisting of miR\u201030e, miR\u2010181b, miR\u201034a, miR\u2010346 and miR\u20107 had significantly increased expression levels with significant combined diagnostic value (AUC:0.713; sensitivity:35.5%; specificity:90.2%). In response to pharmacological treatment, expression levels of miR\u2010132, miR\u2010181b, miR\u2010432 and miR\u201030e were significantly decreased. In addition, the improvement of clinical symptomatology was significantly correlated with the changes of miR\u2010132, miR\u2010181b, miR\u2010212 and miR\u201030e expression levels. Furthermore, the decreases of plasma levels of miR\u2010132 and miR\u2010432 were significantly greater in high\u2010effect subgroup than those in low\u2010effect subgroup after six\u2010week treatment course. We conclude that miR\u201030e, miR\u2010181b, miR\u201034a, miR\u2010346 and miR\u20107 combined as a panel are potentially useful non\u2010invasive biomarkers for schizophrenia diagnosis. Markers miR\u2010132, miR\u2010181b, miR\u201030e and miR\u2010432 are potential indicators for symptomatology improvements, treatment responses and prognosis for schizophrenia patients. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.b.32292","type":"journal-article","created":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T04:03:50Z","timestamp":1423195430000},"page":"170-178","source":"Crossref","is-referenced-by-count":86,"title":["A preliminary analysis of microRNA as potential clinical biomarker for schizophrenia"],"prefix":"10.1002","volume":"168","author":[{"given":"Xin\u2010yang","family":"Sun","sequence":"first","affiliation":[{"name":"Prevention and Treatment Center for Psychological Diseases No.102 Hospital of Chinese People's Liberation Army Changzhou Jiangsu P.R. China"},{"name":"Department of Psychology and Psychiatry Second Military Medical University Shanghai P.R. 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