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We examined the effect of BD\u2010risk polymorphisms at rs10994336 and rs9804190 on the working memory (WM) circuit using functional magnetic resonance imaging (fMRI) data obtained from euthymic patients with BD (n\u2009=\u200941), their psychiatrically healthy first\u2010degree relatives (n\u2009=\u200925) and unrelated individuals without personal or family history of psychiatric disorders (n\u2009=\u200946) while performing the N\u2010back task. In unrelated healthy individuals, the rs10994336\u2010risk\u2010allele was associated with reduced activation of the ventral visual cortical components of the WM circuit while the rs9804190\u2010risk\u2010allele was associated with inefficient hyperactivation of the prefrontal cortical components of the WM. In patients and their healthy relatives, risk alleles at either loci were associated with hyperactivation in the ventral anterior cingulate cortex. Additionally, Rs9804190\u2010risk\u2010allele carriers with BD evidenced abnormal hyperactivation within the posterior cingulate cortex. This study provides new insights on the neurogenetic correlates of allelic variation at different genome\u2010wide supported BD\u2010risk associated<jats:italic>ANK3<\/jats:italic>loci that support their involvement in BD and highlight the modulatory influence of increased background genetic risk for BD. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.b.32294","type":"journal-article","created":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T11:41:08Z","timestamp":1424864468000},"page":"188-196","source":"Crossref","is-referenced-by-count":27,"title":["The effect of<i>ANK3<\/i>bipolar\u2010risk polymorphisms on the working memory circuitry differs between loci and according to risk\u2010status for bipolar disorder"],"prefix":"10.1002","volume":"168","author":[{"given":"Giuseppe","family":"Delvecchio","sequence":"first","affiliation":[{"name":"Social Genetic and Developmental Psychiatry Center Institute of Psychiatry King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danai","family":"Dima","sequence":"additional","affiliation":[{"name":"Social Genetic and Developmental Psychiatry Center Institute of Psychiatry King's College London London UK"},{"name":"Clinical Neurosciences Studies Center Department of Psychiatry Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Frangou","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences Studies Center Department of Psychiatry Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001906"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2004.00117.x"},{"key":"e_1_2_6_4_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4002012"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.011"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg216"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32030"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.04.038"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2006.06.012"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.04.009"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.209"},{"key":"e_1_2_6_13_1","volume-title":"Structured clinical interview for DSM\u2010IV\u2010TR axis I disorders, research version, patient edition. 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