{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:07:20Z","timestamp":1790435240439,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T00:00:00Z","timestamp":1434412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIMH PHS","award":["MH082041"],"award-info":[{"award-number":["MH082041"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:label\/><jats:p>Genome wide array studies have reported limited success in identifying genetic markers conferring risk for suicidal behavior (SB). This may be attributable to study designs with primary outcome other than SB. We performed a GWAS on suicides and cases with a history of nonfatal suicide attempts compared with psychiatric controls and healthy volunteers. A consortium of USA, Canadian and German teams assembled two groups of cases (suicide attempters and suicides, N\u2009=\u2009577) and non\u2010attempter psychiatric and healthy controls (N\u2009=\u20091,233). Logistic regression was used to test genotype\u2010suicidal behavior association. The test was repeated separating suicide attempt and completed suicide as outcomes. No SNP reached genome\u2010wide significance, but several SNPs within STK3, ADAMTS14, PSME2, and TBX20 genes reached<jats:italic>P<\/jats:italic>\u2009&lt;\u20091\u2009\u00d7\u200910<jats:sup>\u22125<\/jats:sup>. The top SNPs for the suicide attempt analysis included two from DPP10, one from CTNNA3 and one from STK32B. In the suicide analysis we found seven SNPs from the TBX20 gene in the top hits. Pathway analysis identified the following pathways: \u201cCellular Assembly and Organization,\u201d \u201cNervous System Development and Function,\u201d \u201cCell Death and Survival,\u201d \u201cImmunological Disease,\u201d \u201cInfectious Disease,\u201d and \u201cInflammatory Response.\u201d The top genes in the SB analysis did not overlap with those in the ideation analysis. No genome wide significant results suggest that susceptibility to SB has genetic risk factors with smaller effect sizes. The strongest candidate genes, ADAMTS14, and PSME2 (both linked to inflammatory response), STK3 (neuronal cell death), and TBX20 (brainstem motor neuron development), have not been previously reported in association with suicide and warrant further study. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.b.32330","type":"journal-article","created":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T13:34:13Z","timestamp":1434461653000},"page":"557-563","source":"Crossref","is-referenced-by-count":97,"title":["A genome\u2010wide association study of suicidal behavior"],"prefix":"10.1002","volume":"168","author":[{"given":"Hanga","family":"Galfalvy","sequence":"first","affiliation":[{"name":"Department of Psychiatry Columbia University New York City New York"},{"name":"Department of Biostatistics Columbia University New York City New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Haghighi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Columbia University New York City New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Hodgkinson","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism National Institutes of Health Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Goldman","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism National Institutes of Health Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Oquendo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Columbia University New York City New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainsley","family":"Burke","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Columbia University New York City New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung\u2010yu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Columbia University New York City New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Giegling","sequence":"additional","affiliation":[{"name":"Psychiatric Clinic Martin\u2010Luther\u2010Universit\u00e4t Halle\u2010Wittenberg Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Rujescu","sequence":"additional","affiliation":[{"name":"Psychiatric Clinic Martin\u2010Luther\u2010Universit\u00e4t Halle\u2010Wittenberg Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Bureau","sequence":"additional","affiliation":[{"name":"Centre de recherche de l'Institut universitaire en sant\u00e9 mentale de Qu\u00e9bec and D\u00e9partement de m\u00e9decine sociale et pr\u00e9ventive Universit\u00e9 Laval Quebec City Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Turecki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry McGill University Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. John","family":"Mann","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Columbia University New York City New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.47.2.343"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfs272"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30042"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010053"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083968"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1099800411424487"},{"key":"e_1_2_6_8_1","first-page":"1","article-title":"The neuroscience of suicidal behaviors: What can we expect from endophenotype strategies?","author":"Courtet P","year":"2011","journal-title":"Transl Psychiatry"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2711"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.11.004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2011.597875"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1996.tb09869.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2013.08.002"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036562"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2010.01.009"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013894"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","unstructured":"OquendoM. 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