{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:10:22Z","timestamp":1789884622664,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T00:00:00Z","timestamp":1444867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 MH085542"],"award-info":[{"award-number":["R01 MH085542"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 MH085548"],"award-info":[{"award-number":["R01 MH085548"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:label\/><jats:p>Patients with Bipolar disorder smoke more than the general population. Smoking negatively impacts mortality and clinical course in Bipolar disorder patients. Prior studies have shown contradictory results regarding the impact of psychosis on smoking behavior in Bipolar disorder. We analyzed a large sample of Bipolar disorder and Schizoaffective disorder, Bipolar Type patients and predicted those with a history of psychosis would be more likely to be nicotine dependent. Data from subjects and controls were collected from the Genomic Psychiatry Cohort (GPC). Subjects were diagnosed with Bipolar disorder without psychosis (N\u2009=\u2009610), Bipolar disorder with psychosis (N\u2009=\u20091544). Participants were classified with or without nicotine dependence. Diagnostic groups were compared to controls (N\u2009=\u200910065) using logistic regression. Among smokers (N\u2009=\u20096157), those with Bipolar disorder had an increased risk of nicotine dependence (OR\u2009=\u20092.5; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Patients with Bipolar disorder with psychosis were more likely to be dependent than Bipolar disorder patients without psychosis (OR\u2009=\u20091.3; <jats:italic>P<\/jats:italic>\u2009=\u20090.03). Schizoaffective disorder, Bipolar Type patients had more risk of nicotine dependence when compared to Bipolar disorder patients with or without psychosis (OR\u2009=\u20091.2; <jats:italic>P<\/jats:italic>\u2009=\u20090.02). Bipolar disorder patients experiencing more severity of psychosis have more risk of nicotine dependence. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.b.32385","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T10:49:14Z","timestamp":1444906154000},"page":"521-524","source":"Crossref","is-referenced-by-count":14,"title":["Nicotine dependence and psychosis in Bipolar disorder and Schizoaffective disorder, Bipolar type"],"prefix":"10.1002","volume":"171","author":[{"given":"Elena","family":"Estrada","sequence":"first","affiliation":[{"name":"Department of Psychiatry and the Behavioral Sciences Keck School of Medicine of the University of Southern California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M.","family":"Hartz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University in St. Louis 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