{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:27:00Z","timestamp":1786976820959,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T00:00:00Z","timestamp":1444694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Studies suggest associations between childhood autistic traits and adolescent psychotic experiences. However, recent research suggests that a general neuropsychiatric problems factor predicts adverse outcomes better than specific diagnostic entities. To examine if the alleged association between autistic traits and psychotic experiences could rather be explained by a general neuropsychiatric problems factor comprising symptoms of ADHD, tic disorder, developmental coordination disorder, and learning disorder, we conducted a prospective cohort study based on the Child and Adolescent Twin Study in Sweden. In addition, we examined the genetic and environmental influences on the associations. A total of 9,282 twins with data on childhood autistic traits and other neuropsychiatric problems, and follow\u2010up data on psychotic experiences at ages 15 and\/or 18 years were included. First, psychotic experiences were regressed on autistic traits and second, the general neuropsychiatric problems factor was added to the model. Auditory hallucinations were analyzed separately from the other psychotic experiences. Finally, twin analyses were employed to disentangle genetic from environmental influences in the observed associations. Replicating prior research, significant associations were found between autistic traits in childhood and auditory hallucinations at ages 15 and 18. However, after controlling for the general neuropsychiatric problems factor, the associations between autistic traits and auditory hallucinations disappeared, whereas the association between the general neuropsychiatric problems factor and auditory hallucinations persisted after controlling for autistic traits. Twin analyses revealed that the association between the general neuropsychiatric problems factor and auditory hallucinations was driven by shared genetic influences. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajmg.b.32386","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T23:40:07Z","timestamp":1444779607000},"page":"153-159","source":"Crossref","is-referenced-by-count":15,"title":["The association between childhood autistic traits and adolescent psychotic experiences is explained by general neuropsychiatric problems"],"prefix":"10.1002","volume":"171","author":[{"given":"Martin","family":"Cederl\u00f6f","sequence":"first","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Pettersson","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Sariaslan","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"\u00d6stberg","sequence":"additional","affiliation":[{"name":"Division of Speech and Language Pathology, Department of Clinical Science Intervention and Technology, Karolinska Institutet Stockholm Sweden"},{"name":"Department of Speech and Language Pathology Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Kelleher","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Royal College of Surgeons in Ireland Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"L\u00e5ngstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"},{"name":"Swedish Prison and Probation Service R&amp;D unit Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara Hellner","family":"Gumpert","sequence":"additional","affiliation":[{"name":"Centre for Psychiatry Research &amp; Education, Department of Clinical Neuroscience Karolinska Institutet &amp; Stockholm County Council Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Lundstr\u00f6m","sequence":"additional","affiliation":[{"name":"Centre for Ethics Law and Mental Health (CELAM) University of Gothenburg Gothenburg Sweden"},{"name":"Gillberg Neuropsychiatry Centre University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Lichtenstein","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,13]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"American Psychiatric Association.1980.Diagnostic and Statistical Manual of Psychiatric Disorders. 3rd ed. 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